223576-64-5

Basic information

• Product Name: Boronic acid, B-(5-chloro-2-benzofuranyl)-
• Synonyms: Boronic acid, B-(5-chloro-2-benzofuranyl)-;(5-Chlorobenzofuran-2-yl)boronic acid;5-chlorobenzofuran-2-boronic acid
• CAS NO: 223576-64-5
• Molecular Formula: C₈H₆BClO₃
• Molecular Weight: 196.39544
• EINECS: -0
• Product Categories: Organic boronic acid
• Mol File: 223576-64-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Boronic acid, B-(5-chloro-2-benzofuranyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Boronic acid, B-(5-chloro-2-benzofuranyl)-(223576-64-5)
• EPA Substance Registry System: Boronic acid, B-(5-chloro-2-benzofuranyl)-(223576-64-5)

Safety Data

• Hazardous Substances Data: 223576-64-5(Hazardous Substances Data)

Usage

Description

Boronic acid, B-(5-chloro-2-benzofuranyl)-, is an organic compound with the chemical formula C7H5BO2Cl. It is a derivative of boronic acid, featuring a 5-chloro-2-benzofuranyl group attached to the boron atom. Boronic acid, B-(5-chloro-2-benzofuranyl)is known for its unique chemical properties and reactivity, making it a valuable component in various chemical reactions and synthesis processes.

Uses

Used in Pharmaceutical Industry:
Boronic acid, B-(5-chloro-2-benzofuranyl)-, is used as a synthetic reagent for the preparation of (ary)benzofuran containing natural products. These natural products have been found to possess significant biological activities, including potential applications in the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
In the field of chemical synthesis, Boronic acid, B-(5-chloro-2-benzofuranyl)-, is used as a reagent for the preparation of quinoxaline compounds. These compounds have been identified for their potential to inhibit PASK (Proline-Alanine-Glutamic Acid-Lysine Serine-Threonine), an enzyme involved in various cellular processes. Inhibiting PASK may be useful in treating diseases associated with its overactivity or dysregulation.
Overall, Boronic acid, B-(5-chloro-2-benzofuranyl)-, is a versatile compound with applications in both the pharmaceutical industry and chemical synthesis. Its unique structure and reactivity make it a valuable tool for the development of new drugs and the synthesis of complex organic molecules.

Upstream product

• 3261-05-0 5-chlorobenzofuran-3(2H)-one 

Downstream Products

• 227802-79-1 5-chloro-2-m-tolyl-benzo[b]furan 
• 67024-72-0 5-chloro-2-(4-chlorophenyl)benzo[b]furan 
• 24472-98-8 5-Chloro-2-(4-methoxy-phenyl)-benzofuran 

Relevant articles and documents

Total synthesis of the 2-arylbenzo[b]furan-containing natural products from Artocarpus

In this study, 2-arylbenzo[b]furan-containing derivatives moracin C (1) and moracin M (4), the natural products from Artocarpus, have been synthesized in highest overall yield to date (1, 7 steps with an overall yield of 41.9%; 4, 6 steps with an overall yield of 56.3%), and we also report the first total synthesis of artoindonesianin B-1 (2), another member of this family, in the same route (8 steps with an overall yield of 11.3%). This discovery provides a concise route for preparing enough amounts of 1, 2, and 4 as well as 2-arylbenzo[b]furan-containing natural product-like analogs (71-74) to explore the biological potential.