22367-12-0

Basic information

• Product Name: 2-(3-CHLORO-PHENYL)-4H-ISOQUINOLINE-1,3-DIONE
• Synonyms: 1,3(2H,4H)-Isoquinolinedione,2-(m-chlorophenyl)- (8CI)
• CAS NO: 22367-12-0
• Molecular Formula: C₁₅H₁₀ClNO₂
• Molecular Weight: 0
• Mol File: 22367-12-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 475.6°Cat760mmHg
• Flash Point: 241.4°C
• Appearance: /
• Density: 1.383g/cm³
• Vapor Pressure: 3.27E-09mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 2-(3-CHLORO-PHENYL)-4H-ISOQUINOLINE-1,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-CHLORO-PHENYL)-4H-ISOQUINOLINE-1,3-DIONE(22367-12-0)
• EPA Substance Registry System: 2-(3-CHLORO-PHENYL)-4H-ISOQUINOLINE-1,3-DIONE(22367-12-0)

Safety Data

• Hazardous Substances Data: 22367-12-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H10ClNO2/c16-11-5-3-6-12(9-11)17-14(18)8-10-4-1-2-7-13(10)15(17)19/h1-7,9H,8H2

Upstream product

• 103-82-2 phenylacetic acid 
• 2909-38-8 m-chlorophenyl isocyanate 
• 703-59-3 homophthalic anhydride 
• 108-42-9 3-chloro-aniline 
• 89-51-0 Homophthalic acid 

Downstream Products

• 220327-64-0 2-(3-Chloro-phenyl)-3-hydroxy-3,4-dihydro-2H-isoquinolin-1-one 
• 220327-65-1 [2-(3-Chloro-phenyl)-1-oxo-1,2,3,4-tetrahydro-isoquinolin-3-yl]-acetic acid 
• 945723-93-3 C₁₇H₁₄ClNO₂ 

Relevant articles and documents

Modelling and Phenotypic Screening of NAP-6 and 10-Cl-BBQ, AhR Ligands Displaying Selective Breast Cancer Cytotoxicity in Vitro

To exploit the interaction of the aryl hydrocarbon receptor (AhR) pathway in developing breast-cancer-specific cytotoxic compounds, we examined the breast cancer selectivity and the docking pose of the AhR ligands (Z)-2-(2-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (NAP-6; 5) and 10-chloro-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one (10-Cl-BBQ; 6). While the breast cancer selectivity of 5 in vitro is known, we discuss the SAR around this lead and, by using phenotypic cell-line screening and the MTT assay, show for the first time that 6 also presents with breast cancer selectivity, notably in the triple-negative (TN) receptor breast cancer cell line MDA-MB-468, the ER+ breast cancer cell lines T47D, ZR-75-1 and the HER2+ breast cancer cell line SKBR3 (GI50 values of 0.098, 0.97, 0.13 and 0.21 μM, respectively). Indeed, 6 is 55 times more potent in MDA-MB-468 cells than normal MCF10A breast cells (GI50 of 0.098 vs 5.4 μM) and more than 130 times more potent than in cell lines derived from pancreas, brain and prostate (GI50 of 0.098 vs 10–13 μM). Molecular docking poses of 5 and 6 together with analogue synthesis and phenotypic screening show the importance of the naphthalene moiety, and an ortho-disposed substituent on the N-phenyl moiety for biological activity.

Flower-shaped ZnO nanoparticles as an efficient, heterogeneous and reusable catalyst in the synthesis of N-arylhomophthalimides and benzannelated isoquinolinones

A simple and green protocol, developed utilizing an efficient, heterogeneous and recyclable catalyst, i.e. zinc oxide nanoparticles (ZnO NPs)-mediated synthesis of N-arylhomophthalimides and benzannelated isoquinolinones, is reported. The structures of th

Synthesis and diuretic activity of 4,5-dihydro-6H-imidazo[4,5,1- ij]quinoline-6-one 6-oxime-O-sulfonic acid derivatives

Using our previously reported 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)- 4(1H)-quinolinone 4-oxime-O-sulfonic acid potassium salt la (M17055) as a lead, a series of tricyclic (2a-o, 3, 4, 5) and tetracyclic (6) quinolinone oxime O-sulfonic acid derivatives were synthesized by ring annulation of the 1-(2-methylbenzoyl) moiety to the quinolinone skeleton. They were compared with furosemide and compound 1a for diuretic activity in dogs; some tricyclic 4,5-dihydro-6H-imidazo[4,5,1-ij]quinoline-6-one 6-oxime-O-sulfonic acid derivatives showed diuretic activity comparable (2c,e) or superior (2m) to the lead compound 1a. These results are discussed on the basis of a comparison of the conformational and electronic characteristics of the relevant compounds with the aid of computer graphics.