223671-53-2

Basic information

• Product Name: 1-Chloroisoquinoline-7-carbaldehyde
• Synonyms: 1-Chloro-7-isoquinolinecarboxaldehyde;7-Isoquinolinecarboxaldehyde,1-chloro;1-Chloro-7-formylisoquinoline, 1-Chloro-7-formyl-2-azanaphthalene;1-Chloroisoquinoline-7-carboxaldehyde
• CAS NO: 223671-53-2
• Molecular Formula: C10H6ClNO
• Molecular Weight: 191.61
• Mol File: 223671-53-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 368℃
• Flash Point: 177℃
• Appearance: /
• Density: 1.364
• Vapor Pressure: 1.28E-05mmHg at 25°C
• Refractive Index: 1.692
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Chloroisoquinoline-7-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloroisoquinoline-7-carbaldehyde(223671-53-2)
• EPA Substance Registry System: 1-Chloroisoquinoline-7-carbaldehyde(223671-53-2)

Safety Data

• Hazardous Substances Data: 223671-53-2(Hazardous Substances Data)

Usage

General Description

1-Chloroisoquinoline-7-carbaldehyde is a chemical compound with the molecular formula C11H7ClNO. It is a yellow liquid with a strong and unpleasant odor. 1-Chloroisoquinoline-7-carbaldehyde is used primarily as a reagent in organic synthesis and as an intermediate in the manufacture of pharmaceuticals and agrochemicals. It has been found to have potential applications in the development of antipsychotic and antifungal medications. Additionally, 1-Chloroisoquinoline-7-carbaldehyde is also used as a building block in the synthesis of a variety of biologically active molecules. Overall, this compound plays a crucial role in the field of medicinal and organic chemistry as a versatile and important intermediate for the production of various pharmaceutical and agricultural products.

InChI:InChI=1/C10H6ClNO/c11-10-9-5-7(6-13)1-2-8(9)3-4-12-10/h1-6H

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 215453-51-3 7-bromo-1-chloroisoquinoline 
• 107-31-3 Methyl formate 

Downstream Products

• 223671-64-5 1-Chloro-7-hydroxymethylisoquinoline 

Relevant articles and documents

Iron-Catalyzed Synthesis of C2 Aryl- and N-Heteroaryl-Substituted Tetrahydropyrans

An iron-catalyzed cyclization of hydroxy allylic derivatives into tetrahydropyrans possessing an N-heteroaryl at C2 is disclosed. The reaction proceeds with good yield and in high diastereoselectivity in favor of the more stable isomer. The diastereoselectivity results from an iron-induced reopening of the tetrahydropyrans, allowing a thermodynamic equilibration. The method allows access to a variety of 2,6-disubstituted as well as 2,4,6-trisubstituted tetrahydropyrans that could be considered as attractive scaffolds for the pharmaceutical industry.

Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-Isoquinolinylguanidines

A series of 1-isoquinolinylguanidines are shown to be potent inhibitors of uPA with selectivity over tPA and plasmin. Potency is enhanced by the presence of a 4-halo and a 7-aryl substituent, particularly when substituted by a 3-carboxylic acid group. Compound 13j (UK-356,202) combines excellent potency and selectivity, and has been selected as a candidate for clinical evaluation.