223926-91-8

Basic information

• Product Name: 2-butyl-6-hydroxy-5-phenethyl-3H-pyrimidin-4-one
• Synonyms: 2-butyl-6-hydroxy-5-phenethyl-3H-pyrimidin-4-one
• CAS NO: 223926-91-8
• Molecular Weight: 272.347
• Mol File: 223926-91-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-butyl-6-hydroxy-5-phenethyl-3H-pyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-butyl-6-hydroxy-5-phenethyl-3H-pyrimidin-4-one(223926-91-8)
• EPA Substance Registry System: 2-butyl-6-hydroxy-5-phenethyl-3H-pyrimidin-4-one(223926-91-8)

Safety Data

• Hazardous Substances Data: 223926-91-8(Hazardous Substances Data)

Upstream product

• 120790-93-4 dimethyl 2-(2-phenylethyl)propanedioate 
• 18257-46-0 pentanamidine hydrochloride 

Downstream Products

• 272438-22-9 4,6-dichloro-2-butyl-5-(2'-phenylethyl)-pyrimidine 
• 223927-28-4 2-butyl-6-chloro-5-phenethyl-1H-pyrimidine-4-one 
• 223927-30-8 2-butyl-5-phenethyl-3H-pyrimidin-4-one 
• 223926-99-6 phosphoric acid 2-butyl-6-(diethoxy-phosphoryloxy)-5-phenethyl-pyrimidin-4-yl ester diethyl ester 
• 223926-97-4 methanesulfonic acid 2-butyl-6-oxo-5-phenethyl-1,6-dihydro-pyrimidin-4-yl ester 
• 223926-93-0 2-butyl-6-methoxy-5-phenethyl-3H-pyrimidin-4-one 
• 223926-95-2 2-butyl-6-ethoxy-5-phenethyl-3H-pyrimidin-4-one 

Relevant articles and documents

Angiotensin II receptor antagonistic 1,2,4-triazin-5-one derivatives

Disclosed are novel 1,2,4-triazin-5-one biphenyl derivatives having structural formula (I) useful as non-peptide antagonists of angiotensin II receptor: where R1 represents alkyl, cycloalkyl, or substituted or unsubstituted aryl; R2 represents alkyl, substituted or unsubstituted aryl, or arylalkyl; A and D independently represent C-R3, N, NH or C=O, wherein when A and D independently denote C-R3 or N, b and c are independently a double bond, and when A and D independently denote NH or C=O, b and c are independently a single bond; provided that b and c are not both double bonds; and R3 is hydrogen, dialkylphosphonate or halogen; and pharmaceutically acceptable salts thereof. Also disclosed is the use of the compounds of formula (I) as non-peptide antagonists of angiotensin II receptor, in the treatment of cardiovascular diseases, in particular hypertension and congestive heart failure.