22395-24-0

Basic information

• Product Name: 3',4',7-TRIMETHOXYFLAVONE
• Synonyms: 3',4',7-TRIMETHOXYFLAVONE;7,3',4'-TRIMETHOXYFLAVONE;TRIMETHOXYFLAVONE,3',4',7-;3,4,7-TRIMETHOXYFLAVONE 97%;TRIMETHOXYFLAVONE,3',4',7-(RG);2-(3,4-Dimethoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
• CAS NO: 22395-24-0
• Molecular Formula: C₁₈H₁₆O₅
• Molecular Weight: 312.32
• Product Categories: Tri-substituted Flavones
• Mol File: 22395-24-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 179-181°C
• Boiling Point: 477.4 °C at 760 mmHg
• Flash Point: 212 °C
• Appearance: /
• Density: 1.242 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3',4',7-TRIMETHOXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4',7-TRIMETHOXYFLAVONE(22395-24-0)
• EPA Substance Registry System: 3',4',7-TRIMETHOXYFLAVONE(22395-24-0)

Safety Data

• Hazardous Substances Data: 22395-24-0(Hazardous Substances Data)

Usage

General Description

3',4',7-Trimethoxyflavone is a naturally occurring chemical compound belonging to the flavonoid class of compounds. It is found in various plants and has been studied for its potential medicinal properties. 3',4',7-Trimethoxyflavone has been shown to possess antioxidant, anti-inflammatory, and anti-cancer activities. It has also been studied for its potential effects on neurodegenerative diseases such as Alzheimer's and Parkinson's. Additionally, 3',4',7-Trimethoxyflavone has been investigated for its potential benefits in improving cardiovascular health and for its antibacterial and antiviral properties. Overall, this compound shows promise as a potential therapeutic agent for various health conditions.

Upstream product

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• 150-19-6 O-methylresorcine 
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• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 33513-36-9 2-(3,4-dimethoxy-phenyl)-7-hydroxy-chromen-4-one 
• 74-88-4 methyl iodide 
• 25015-92-3 2-chloro-1-(2,4-dihydroxyphenyl)ethanone 
• 755722-84-0 imine 
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Downstream Products

• 2150-11-0 3',4',7-trihydroxyflavone 

Relevant articles and documents

Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor

The present study aimed to characterize and investigate 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one (22) as a novel selective COX-2 inhibitor. The data collected from the single X-ray crystallographic analysis and in silico study

Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalconesviapalladium(ii)-catalyzed oxidative cyclization

Divergent and versatile synthetic routes to flavones and flavanonesviaefficient Pd(ii) catalysis are disclosed. These Pd(ii) catalyses expediently provide a variety of flavones and flavanones from 2′-hydroxydihydrochalcones as common intermediates, depending on oxidants and additives,viadiscriminate oxidative cyclization sequences involving dehydrogenation, respectively, in a highly atom-economic manner.

Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors

The biological effects of flavonoids on mammal cells are diverse, ranging from scavenging free radicals and anti-cancer activity to anti-influenza activity. Despite appreciable effort to understand the anti-influenza activity of flavonoids, there is no clear consensus about their precise mode-of-action at a cellular level. Here, we report the development and validation of a screening assay based on AlphaScreen technology and illustrate its application for determination of the inhibitory potency of a large set of polyols against PA N-terminal domain (PA-Nter) of influenza RNA-dependent RNA polymerase featuring endonuclease activity. The most potent inhibitors we identified were luteolin with an IC50 of 72 ± 2 nM and its 8-C-glucoside orientin with an IC50 of 43 ± 2 nM. Submicromolar inhibitors were also evaluated by an in vitro endonuclease activity assay using single-stranded DNA, and the results were in full agreement with data from the competitive AlphaScreen assay. Using X-ray crystallography, we analyzed structures of the PA-Nter in complex with luteolin at 2.0 ? resolution and quambalarine B at 2.5 ? resolution, which clearly revealed the binding pose of these polyols coordinated to two manganese ions in the endonuclease active site. Using two distinct assays along with the structural work, we have presumably identified and characterized the molecular mode-of-action of flavonoids in influenza-infected cells.