22397-92-8Relevant articles and documents
(3R)-3-Amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Nitta, Aiko,Fujii, Hideaki,Sakami, Satoshi,Nishimura, Yutaka,Ohyama, Tomofumi,Satoh, Mikiya,Nakaki, Junko,Satoh, Shiho,Inada, Chifumi,Kozono, Hideki,Kumagai, Hiroki,Shimamura, Masahiro,Fukazawa, Tominaga,Kawai, Hideki
scheme or table, p. 5435 - 5438 (2009/05/30)
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides and 3-amino-N-(4-aryltetrahydropyran-4-yl)butanamides were synthesized and evaluated as dipeptidyl peptidase IV (DPP-IV) inhibitors. Derivatives incorporating the 6-substituted benzothiazole group showed highly potent DPP-IV inhibitory activity. Oral administration of (3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide (12u) reduced blood glucose excursion in an oral glucose tolerance test.
Stereoselectivity in the Reactions between the Anion of 4-Phenyl-5,6-dihydro-2H-thiopyran 1-Oxide and Electrophiles
Crumbie, Robyn L.,Ridley, Damon D.,Steel, Peter J.
, p. 119 - 132 (2007/10/02)
Treatment of the anion (17), prepared from the six-membered ring allylic sulfoxide 4-phenyl-5,6-dihydro-2H-thiopyran 1-oxide (8) with primary alkyl halides at -78 deg C, affords trans-2-alkyl-4-phenyl-5,6-dihydro-2H-thiopyran 1-oxides exclusively.The ster
