22401-25-8Relevant articles and documents
Flexible diphosphonic acids for the isolation of uranyl hybrids with heterometallic UVI = O - ZnII cation-cation interactions
Tian, Tao,Yang, Weiting,Wang, Hao,Dang, Song,Sun, Zhong-Ming
, p. 8288 - 8290 (2013)
A family of uranyl diphosphonates have been hydrothermally synthesized using various flexible diphosphonic acids and Zn(UO2)(OAc) 4·7H2O in the presence of bipy or phen. Single-crystal X-ray analyses indicate that these compounds represent the first examples of uranyl phosphonates with heterometallic UVI = O - Zn II cation-cation interactions.
Direct conversion of phosphonates to phosphine oxides: An improved synthetic route to phosphines including the first synthesis of methyl JohnPhos
Kendall, Alexander J.,Salazar, Chase A.,Martino, Patrick F.,Tyler, David R.
supporting information, p. 6171 - 6178 (2015/02/19)
The synthesis of tertiary phosphine oxides from phosphonates was achieved reliably and in good to excellent yields using stoichiometric amounts of alkyl or aryl Grignard reagents and sodium trifluoromethanesulfonate (NaOTf). In the absence of the NaOTf additive, covalent coordination oligomers of magnesium and phosphorus species dominate the reaction, producing very low yields of phosphine oxide, but high conversions of the phosphonate starting material. Mechanistic studies revealed that a five-coordinate phosphorus species - not a phosphinate - is the reaction intermediate. A diverse array of phosphonates was converted to phosphine oxides using a variety of Grignard reagents for direct carbon-phosphorus functionalization. This new methodology especially simplifies the synthesis of dimethylphosphino (RPMe2)-type phosphines by using air-, water-, and silica-stable intermediates. To highlight this reaction, a new Buchwald-type ligand ([1,1′-biphenyl]-2-yldimethylphosphine, or methyl JohnPhos) and a classic bidentate phosphine, bis(diphenylphosphino)propane (dppp), were synthesized in excellent yields.
Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis
Andaloussi, Mounir,Lindh, Martin,Bj?rkelid, Christofer,Suresh, Surisetti,Wieckowska, Anna,Iyer, Harini,Karlén, Anders,Larhed, Mats
scheme or table, p. 5403 - 5407 (2011/10/12)
Two series of FR900098/fosmidomycin analogs were synthesized and evaluated for MtDXR inhibition and Mycobacterium tuberculosis whole-cell activity. The design rationale of these compounds involved the exchange of either the phosphonic acid or the hydroxamic acid part for alternative acidic and metal-coordinating functionalities. The best inhibitors provided IC50 values in the micromolar range, with a best value of 41 μM.
