22404-87-1

Basic information

• Product Name: N,N'-methylenebis(4-chlorobenzamide)
• Synonyms: N,N'-methylenebis(4-chlorobenzamide)
• CAS NO: 22404-87-1
• Molecular Weight: 323.178
• Mol File: 22404-87-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N,N'-methylenebis(4-chlorobenzamide)(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-methylenebis(4-chlorobenzamide)(22404-87-1)
• EPA Substance Registry System: N,N'-methylenebis(4-chlorobenzamide)(22404-87-1)

Safety Data

• Hazardous Substances Data: 22404-87-1(Hazardous Substances Data)

Upstream product

• 75-05-8 acetonitrile 
• 758-96-3 N,N-dimethyl-propanamide 
• 619-56-7 4-chlorobenzamide 
• 104-88-1 4-chlorobenzaldehyde 
• 67-68-5 dimethyl sulfoxide 
• 127-19-5 N,N-dimethyl acetamide 

Relevant articles and documents

Ammonium persulfate activated DMSO as a one-carbon synthon for the synthesis of methylenebisamides and other applications

Activation of DMSO to work as an economical and environmentally benign one-carbon synthon has been achieved by using a bench-top reagent ammonium persulfate for general and efficient access to symmetrical methylenebisamides from primary amides. This methodology was used to achieve a three-component Mannich reaction using acetophenone, saccharin and DMSO to furnish a β-amino ketone. It also provided a metal-free synthesis of thiadiazole and bis(phenyl)methane. Effectively, this method uses DMSO as a safer surrogate to formaldehyde. A mechanism for methylenebisamide formation involving radical intermediates has been proposed based on mechanistic studies.

Selectfluor-mediated oxidative methylenation of amide with N, N -dimethylpropanamide for N, N ′-methylenebisamide synthesis

A simple and efficient approach for the synthesis of N,N′-methylenebisamides through a Selectfluor-mediated oxidative reaction of aromatic amides and N,N-dimethylpropanamide (DMP) is described. Remarkable results clearly reveal that DMP plays a dual role in this reaction, as both a one-carbon source and an environment-friendly solvent. Moreover, the process provides new strategies for the synthesis of bisamides with advantages of operationally simple, insensitive to atmospheric conditions, and good to high yields.

A methylene-bis-amide derivatives method for the preparation of

The invention belongs to the technical field of bisamide organic compounds and discloses a methylenebisamide derivative and a preparation method thereof. The structural formula of the methylenebisamide derivative is shown in the specification. The preparation method comprises the following steps: with benzamide and N, N-dimethylacetamide as reactants, putting the reactants in a reactor, adding water, sodium persulfate and ceric ammonium nitrate and carrying out reaction for 12h at the temperature of 110 DEG C in the air atmosphere to obtain the methylenebisamide compound. According to the preparation method disclosed by the invention, with water as a solvent, the preparation method is environmentally friendly and green; the synthetic method is simple in operation, efficient in reaction, high in reaction selectivity, small in amount of by-products and suitable for industrial production and has the yield generally being 43-86 percent.