224054-42-6

Basic information

• Product Name: ((propane-1,3-diylbis(oxy))bis(4,1-phenylene))dimethanamine
• Synonyms: ((propane-1,3-diylbis(oxy))bis(4,1-phenylene))dimethanamine
• CAS NO: 224054-42-6
• Molecular Weight: 286.374
• Mol File: 224054-42-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ((propane-1,3-diylbis(oxy))bis(4,1-phenylene))dimethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: ((propane-1,3-diylbis(oxy))bis(4,1-phenylene))dimethanamine(224054-42-6)
• EPA Substance Registry System: ((propane-1,3-diylbis(oxy))bis(4,1-phenylene))dimethanamine(224054-42-6)

Safety Data

• Hazardous Substances Data: 224054-42-6(Hazardous Substances Data)

Upstream product

• 7476-06-4 1,3-bis(4-cyanophenoxy)propane 
• 767-00-0 4-cyanophenol 

Relevant articles and documents

The Delicate Balance of Preorganisation and Adaptability in Multiply Bonded Host–Guest Complexes

Rigidity and preorganisation are believed to be required for high affinity in multiply bonded supramolecular complexes as they help reduce the entropic penalty of the binding event. This comes at the price that such rigid complexes are sensitive to small geometric mismatches. In marked contrast, nature uses more flexible building blocks. Thus, one might consider putting the rigidity/high-affinity notion to the test. Multivalent crown/ammonium complexes are ideal for this purpose as the monovalent interaction is well understood. A series of divalent complexes with different spacer lengths and rigidities has thus been analysed to correlate chelate cooperativities and spacer properties. Too long spacers reduce chelate cooperativity compared to exactly matching ones. However, in contrast to expectation, flexible guests bind with chelate cooperativities clearly exceeding those of rigid structures. Flexible spacers adapt to small geometric host–guest mismatches. Spacer–spacer interactions help overcome the entropic penalty of conformational fixation during binding and a delicate balance of preorganisation and adaptability is at play in multivalent complexes.

Sulfonamide bridging compounds that inhibit tryptase activity

The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediated by mast cell activation. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds and methods for treating or preventing an inflammatory disease.