224192-24-9

Basic information

• Product Name: methyl (2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}-4-hydroxybutanoate
• Synonyms: methyl (2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}-4-hydroxybutanoate
• CAS NO: 224192-24-9
• Molecular Weight: 333.382
• Mol File: 224192-24-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}-4-hydroxybutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}-4-hydroxybutanoate(224192-24-9)
• EPA Substance Registry System: methyl (2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}-4-hydroxybutanoate(224192-24-9)

Safety Data

• Hazardous Substances Data: 224192-24-9(Hazardous Substances Data)

Upstream product

• 40856-59-5 tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate 

Downstream Products

• 40856-59-5 tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate 
• 224192-25-0 (S)-(-)-methyl 2-[bis(tert-butoxycarbonyl)amino]-4-iodobutanoate 
• 101650-14-0 methyl (2S)-2-(tert-butoxycarbonyl)amino-4-iodobutanoate 
• 108787-91-3 Boc-Arg(Boc)2OH 
• 21887-64-9 N₂-(tert-butoxycarbonyl)-L-ornithine 
• 395095-62-2 C₂₀H₃₆F₂NO₁₀P 
• 534602-95-4 {1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-heptadecyl}-carbamic acid tert-butyl ester 
• 534602-94-3 {1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-hydroxy-heptadec-3-enyl}-carbamic acid tert-butyl ester 
• 534602-93-2 {1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-heptadec-3-enyl}-carbamic acid tert-butyl ester 
• 534602-92-1 [3-tert-butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxy)-2-oxo-pentyl]-phosphonic acid dimethyl ester 
• 534602-91-0 2-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester 
• 902468-38-6 (3S)-[bis(tert-butyloxycarbonyl)amino]-5-(tert-butyldiphenylsilanyloxy)-piperidine-2-one 
• 902468-37-5 (2S)-[bis(tert-butyloxycarbonyl)amino]-4-(tert-butyldiphenylsilanyloxy)-4-cyanobutyric acid methyl ester 
• 67198-86-1 (R)-2-[(tert-butoxycarbonyl)amino]butano-4-lactone 

Relevant articles and documents

Synthesis and evaluation of acyl protein thioesterase 1 (APT1) inhibitors

Lipid-modified proteins play decisive roles in important biological processes such as signal transduction, organisation of the cytoskeleton and vesicular transport. Lipidation of these proteins is essential for correct biological function. Among the modifications with lipids, prenylation and myristoylation are well understood. However, the machinery of palmitoylation is still under investigation. Recently, an enzyme, acyl protein thioesterase 1 (APT1), that may play a regulatory role in the palmitoylation cycle of HRas and G-protein a subunits, was purified. Motivated by this work, several inhibitors of APT1 were designed, synthesized and biologically evaluated leading to highly active compounds.