22422-16-8Relevant articles and documents
Antifungal cyclopentenediones from Piper coruscans
Li, Xing-Cong,Ferreira, Daneel,Jacob, Melissa R.,Zhang, Qifeng,Khan, Shabana I.,ElSohly, Hala N.,Nagle, Dale G.,Smillie, Troy J.,Khan, Ikhlas A.,Walker, Larry A.,Clark, Alice M.
, p. 6872 - 6873 (2004)
Coruscanones A and B, two new antifungal cyclopentenedione derivatives, have been isolated from Piper coruscans and their structures elucidated by spectroscopic and chemical methods. Coruscanone A exhibits significant antifungal activity against Candida a
Vanadium-Catalyzed Coupling of Allenols with Electrophilic Halide Sources for the Formation of α-Halo-α′,β′-unsaturated Ketones
Trost, Barry M.,Tracy, Jacob S.,Yusoontorn, Tas
supporting information, p. 1207 - 1211 (2019/02/14)
A vanadium-catalyzed coupling of allenylic alcohols with electrophilic halide sources to form α-halo-α′,β′-unsaturated ketones is described. The process proceeds through a metal enolate formed from the 1,3-transposition of an allenol that is initiated by
Synthesis of α,β-unsaturated α′-haloketones through the chemoselective addition of halomethyllithiums to Weinreb amides
Pace, Vittorio,Castoldi, Laura,Holzer, Wolfgang
, p. 7764 - 7770 (2013/09/02)
A straightforward synthesis of variously functionalized α,β-unsaturated α′-haloketones has been achieved through the chemoselective addition of halomethyllithium carbenoids to Weinreb amides at -78 C. A comparative study employing the corresponding esters under the same reaction conditions pointed out that the instability of the tetrahedral intermediate formed from the latter is responsible for the observed formation of carbinols instead of the desired haloketones.