224298-18-4

Basic information

• Product Name: 5'-O-(N⁶-benzoyl-2'-deoxyadenosyl) 3'-O-<5'-O-(dimethoxytrityl)thymidine> O-β-cyanoethyl phosphorothioate
• CAS NO: 224298-18-4
• Molecular Weight: 1031.05
• Mol File: 224298-18-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5'-O-(N⁶-benzoyl-2'-deoxyadenosyl) 3'-O-<5'-O-(dimethoxytrityl)thymidine> O-β-cyanoethyl phosphorothioate(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(N⁶-benzoyl-2'-deoxyadenosyl) 3'-O-<5'-O-(dimethoxytrityl)thymidine> O-β-cyanoethyl phosphorothioate(224298-18-4)
• EPA Substance Registry System: 5'-O-(N⁶-benzoyl-2'-deoxyadenosyl) 3'-O-<5'-O-(dimethoxytrityl)thymidine> O-β-cyanoethyl phosphorothioate(224298-18-4)

Safety Data

• Hazardous Substances Data: 224298-18-4(Hazardous Substances Data)

Upstream product

• 98796-51-1 5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] 
• 25152-96-9 N⁶-benzoyl-3'-(methoxyacetyl)-2'-deoxyadenosine 
• 224186-77-0 4-oxo-pentanoic acid 5-(6-benzoylamino-purin-9-yl)-2-[[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-(2-cyano-ethoxy)-phosphanyloxymethyl]-tetrahydro-furan-3-yl ester 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 85231-45-4 N-benzoyl-3'-O-levulinoyl-2'-deoxy-β-D-adenosine 

Relevant articles and documents

Investigation of a facile synthetic method for phosphorothioate dimer synthons in oligonucleotide phosphorothioates synthesis

A facile synthetic method of a phosphorothioate dimer block was investigated. Dinucleoside phosphite triester intermediates were obtained in one-pot synthesis by the coupling of a protected nucleoside bearing free 5'- OH and a protected nucleoside bearing free 3'-OH in the presence of phosphorous trichloride (PCl3) and 1,2,4-triazole. The intermediates were easily sulfurized to afford the desired phosphorothioate dimer blocks in 33- 64% overall yields.