22446-41-9 Usage
Description
3-Hydroxyphenylacetamide is an organic compound that serves as an intermediate in the synthesis of various pharmaceuticals and chemical compounds. It is characterized by the presence of a hydroxyl group attached to a phenyl ring and an amide group connected to an acetic acid moiety. This unique structure endows 3-hydroxyphenylacetamide with versatile chemical properties and potential applications in different fields.
Uses
Used in Pharmaceutical Industry:
3-Hydroxyphenylacetamide is used as a key intermediate in the synthesis of [18F]Maleimide-based Glycogen synthase kinase-3β (GSK-3β) ligands. These ligands are specifically designed for use in positron emission tomography (PET) imaging, a non-invasive diagnostic technique that allows for the visualization of molecular processes within the body.
In the context of PET imaging, 3-hydroxyphenylacetamide plays a crucial role in the development of radiotracers that can selectively bind to GSK-3β, a protein kinase involved in various cellular processes, including glycogen synthesis, cell cycle regulation, and gene expression. Abnormalities in GSK-3β activity have been implicated in several neurological disorders, such as Alzheimer's disease and bipolar disorder, making it an important target for diagnostic and therapeutic interventions.
By incorporating 3-hydroxyphenylacetamide into the structure of [18F]Maleimide-based GSK-3β ligands, researchers can create radiotracers that exhibit high affinity and selectivity for GSK-3β. This enables the PET imaging technique to detect and monitor the activity of this enzyme in vivo, providing valuable insights into the underlying mechanisms of diseases associated with GSK-3β dysregulation and guiding the development of targeted therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 22446-41-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,4,4 and 6 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 22446-41:
(7*2)+(6*2)+(5*4)+(4*4)+(3*6)+(2*4)+(1*1)=89
89 % 10 = 9
So 22446-41-9 is a valid CAS Registry Number.
InChI:InChI=1S/C8H9NO2/c9-8(11)5-6-2-1-3-7(10)4-6/h1-4,10H,5H2,(H2,9,11)
22446-41-9Relevant articles and documents
[18F]MALEIMIDE-BASED GLYCOGEN SYNTHASE KINASE-3BETA LIGANDS FOR POSITRON EMISSION TOMOGRAPHY IMAGING AND RADIOSYNTHESIS METHOD
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Page/Page column 51; 52, (2018/08/03)
The present invention provides a compound having the structure: (Formula I), and a method of inhibiting Glycogen synthase kinase-3 β (GSK-3β) in a subject comprising administering to the subject said compound, so as to thereby inhibit the GSK-3β in the subject.
Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity
Kamiyama, Akane,Nakajima, Mado,Han, Liyou,Wada, Kei,Mizutani, Masaharu,Tabuchi, Yukiko,Kojima-Yuasa, Akiko,Matsui-Yuasa, Isao,Suzuki, Hideyuki,Fukuyama, Keiichi,Watanabe, Bunta,Hiratake, Jun
supporting information, p. 5340 - 5352 (2016/10/24)
γ-Glutamyl transpeptidase (GGT, EC 2.3.2.2) that catalyzes the hydrolysis and transpeptidation of glutathione and its S-conjugates is involved in a number of physiological and pathological processes through glutathione metabolism and is an attractive phar
