2246-20-0

Basic information

• Product Name: 3-Methoxy-17-methylmorphinan-6-one
• Synonyms: 3-Methoxy-17-methylmorphinan-6-one
• CAS NO: 2246-20-0
• Molecular Weight: 0
• Mol File: 2246-20-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Methoxy-17-methylmorphinan-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxy-17-methylmorphinan-6-one(2246-20-0)
• EPA Substance Registry System: 3-Methoxy-17-methylmorphinan-6-one(2246-20-0)

Safety Data

• Hazardous Substances Data: 2246-20-0(Hazardous Substances Data)

Upstream product

• 1092-95-1 C₁₉H₂₃NO₂ 
• 1357172-85-0 3-methoxy-17-(2,2,2-trichloroethoxycarbonyl)morphinan-6-spiro-2'-(1',3'-dioxolane) 
• 1372779-45-7 17-cyclopropylmethyl-3-methoxymorphinan-6-spiro-2'-(1',3'-dioxolane) 
• 1043876-55-6 C₂₃H₃₁NO₄ 
• 1069111-48-3 17-cyclopropylmethyl-8,14-dehydro-3-methoxymorphinan-6-spiro-2'-(1',3'-dioxolane) 
• 1227681-13-1 (4bS,9R)-3-methoxy-11-methyl-6-oxo-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthren-4-yl trifluoromethanesulfonate 
• 50-00-0 formaldehyd 
• 4978-44-3 3-methoxy-6-keto-normorphinan 
• 1612-46-0 7,8-didehydro-3-methoxy-17-methylmorphinan-6-one 
• 76-57-3 codeine 
• 125-29-1 Hydrocodone 
• 847-86-9 (-)-Dihydrothebainon 
• 467-98-1 7,8-didehydro-4-hydroxy-3-methoxy-17-methyl-morphinan-6-one 
• 74924-36-0 dihydrothebainone-4-phenyl ether ethylene glycol ketal 

Relevant articles and documents

Design and synthesis of novel delta opioid receptor agonists and their pharmacologies

We re-examined the accessory site of the 4,5-epoxymorphinan skeleton by camdas conformational analysis in an effort to deign novel δ opioid receptor antagonists. We synthesized three novel compounds (SN-11, 23 and 28) with a 10-methylene bridge and withou

Synthesis and pharmacological evaluation of aminothiazolomorphinans at the Mu and Kappa opioid receptors

Previous studies with aminothiazolomorphinans suggested that this class of opioid ligands may be useful as a potential pharmacotherapeutic to decrease drug abuse. Novel aminothiazole derivatives of cyclorphan were prepared to evaluate a series of aminothiazolomorphinans with varying pharmacological properties at the κ opioid receptor (KOR) and μ opioid receptor (MOR). This study was focused on exploring the regioisomeric analogs with the aminothiazole on the C-ring of the morphinan skeleton. Receptor binding and [35S] GTPγS binding assays were used to characterize the affinity and pharmacological properties of the aminothiazolomorphinans. Intracranial self-stimulation (ICSS) was used to compare the effects of a representative aminothiazolomorphinan with the morphinan mixed-KOR/MOR agonist butorphan (MCL-101) on brain-stimulation reward.

Rapid access to morphinones: removal of 4,5-ether bridge with Pd-catalyzed triflate reduction

A new synthetic method for the removal of the 4,5-bridged ether moiety of several opioids has been developed. This process offers a faster, simpler synthetic route to obtain the morphinone scaffold in high yields without the need for protection of the ketone moiety.