2246-42-6

Basic information

• Product Name: 2-methoxynaphthalen-1-amine
• Synonyms: 2-methoxynaphthalen-1-amine;2-Methoxy-1-naphthalenamine;2-Methoxy-naphthalen-1-ylamine
• CAS NO: 2246-42-6
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.21114
• EINECS: 218-835-6
• Mol File: 2246-42-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 327.4°Cat760mmHg
• Flash Point: 166.1°C
• Appearance: /
• Density: 1.156g/cm³
• Vapor Pressure: 0.000203mmHg at 25°C
• Refractive Index: 1.655
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-methoxynaphthalen-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxynaphthalen-1-amine(2246-42-6)
• EPA Substance Registry System: 2-methoxynaphthalen-1-amine(2246-42-6)

Safety Data

• Hazardous Substances Data: 2246-42-6(Hazardous Substances Data)

Usage

General Description

2-methoxynaphthalen-1-amine, also known as 2-methoxy-1-naphthylamine, is an organic chemical compound with the molecular formula C11H11NO. It is a derivative of naphthalene and is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. 2-methoxynaphthalen-1-amine is an aromatic amine, which makes it a versatile precursor for the production of dyes, pigments, and other organic compounds. It is often used as an intermediate in the manufacture of pesticide and herbicide products. Additionally, 2-methoxynaphthalen-1-amine has potential applications in the field of medicinal chemistry due to its structural properties and reactivity in various chemical reactions. Overall, this compound serves as an important chemical building block with diverse uses in the pharmaceutical, agricultural, and chemical industries.

InChI:InChI=1/C11H11NO/c1-13-10-7-6-8-4-2-3-5-9(8)11(10)12/h2-7H,12H2,1H3

Upstream product

• 13101-92-3 1-chloro-2-methoxynaphthalene 
• 67-56-1 methanol 
• 20937-86-4 2-azidonaphthalene 
• 64-19-7 acetic acid 
• 2036-46-6 1-phenylazo-2-methoxynaphthalene 
• 64-17-5 ethanol 
• 77262-88-5 1-(4-methylphenylazo)-2-methoxynaphthalene 
• 77262-87-4 1-(3-methylphenylazo)-2-methoxynaphthalene 
• 111180-79-1 1-azido-2-methoxynaphthalene 
• 135-19-3 β-naphthol 
• 93-04-9 2-Methoxynaphthalene 
• 88-75-5 2-hydroxynitrobenzene 
• 147506-15-8 naphthalene-2-methoxy-1-sulphonic acid 
• 4900-66-7 2-methoxy-1-nitronaphthalene 

Downstream Products

• 85-04-1 N-(2-methoxy-[1]naphthyl)-acetamide 
• 108979-03-9 (2-methoxynaphthalen-1-yl)(phenyl)sulfane 
• 874514-06-4 N-(2-methoxy-[1]naphthyl)-toluene-4-sulfonamide 
• 1888-41-1 2-methoxy-1-naphthol 
• 239-01-0 11H-benzo[a]carbazole 
• 859495-62-8 N-(4-bromo-2-methoxy-[1]naphthyl)-toluene-4-sulfonamide 
• 101732-30-3 N-(2-methoxy-4-nitro-[1]naphthyl)-toluene-4-sulfonamide 
• 108980-58-1 1-benzenesulfonyl-2-methoxy-naphthalene 
• 14847-35-9 2-Oxo-2,3-dihydro-1H-naphtho<2,1-b><1,4>oxazine 
• 83710-61-6 1-bromo-7-methoxy-naphthalene 

Relevant articles and documents

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ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF

Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.

Metal-free Semiconductor Photocatalysis for sp2 C?H Functionalization with Molecular Oxygen

Designing metal-free catalysts for solar energy conversion is a long-standing challenge in semiconductor photoredox catalysis (SPC). With visible-light-responsive hexagonal boron carbon nitride (h-BCN) as a non-metal photocatalyst, this system affords C?H/N?H coupling products with broad substitution tolerance and high efficiency with molecular oxygen as the terminal oxidant. The catalyst exhibits remarkable performance for the selective C?H functionalization of electron-rich arenes to C?N products (yields up to 95 %) and good stability (6 recycles). Both nitrogen heteroarenes and amine salts are competent coupling nucleophiles. Mechanically, the reactive oxygen species are superoxide anion radical (O2?.) and H2O2, which are proved by electron spin resonance (ESR) data, KI-starch, and control experiments. In addition, kinetic isotope effect (KIE) experiments indicate that C?H bond cleavage is not involved in the rate limiting step. This semiconductor-based photoredox system allows for C?H amination free of any metals, ligands, strong oxidants, and additives. It provides a complementary avenue to C?H functionalizations and enables synthetic applications efficiently in a sustainable manner.