2246-46-0

Basic information

• Product Name: 4-(2-THIAZOLYLAZO)RESORCINOL
• Synonyms: 3-Benzenediol,4-(2-thiazolylazo)-1;4-(2-thiazolylazo)-3-benzenediol;TAR;4-(2-THIAZOLYLAZO)RESORCINOL;4-(2-THIAZOYLAZO)RESORCINOL;2-(2,4-DIHYDROXYPHENYLAZO)THIAZOLE;4-(thiazol-2-ylazo)resorcinol;TAR [=4-(2-Thiazolylazo)resorcinol] [Metal indicator and spectrophotometric reagent for transition metals]
• CAS NO: 2246-46-0
• Molecular Formula: C₉H₇N₃O₂S
• Molecular Weight: 221.24
• EINECS: 218-836-1
• Product Categories: Azobennzenes, etc. (Chelating Reagents);Analytical Chemistry;Azo Compounds;Chelating Reagents
• Mol File: 2246-46-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 211 °C (dec.)(lit.)
• Boiling Point: 402.9°Cat760mmHg
• Flash Point: 197.4°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 3.26E-07mmHg at 25°C
• Refractive Index: 1.734
• Solubility: almost transparency in hot EtOH50vol%
• PKA: 7.99±0.35(Predicted)
• BRN: 204257
• CAS DataBase Reference: 4-(2-THIAZOLYLAZO)RESORCINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-THIAZOLYLAZO)RESORCINOL(2246-46-0)
• EPA Substance Registry System: 4-(2-THIAZOLYLAZO)RESORCINOL(2246-46-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 2246-46-0(Hazardous Substances Data)

Usage

Description

4-(2-Thiazolylazo)resorcinol is an organic compound with the molecular formula C9H7N3OS. It is a dark, viscous, usually pungent substance, derived from the destructive distillation of various organic compounds. 4-(2-THIAZOLYLAZO)RESORCINOL has been found to possess therapeutic properties, particularly in the treatment of certain skin conditions.

Uses

Used in Pharmaceutical Industry:
4-(2-Thiazolylazo)resorcinol is used as a therapeutic agent for the treatment of psoriasis. It exhibits anti-inflammatory and immunomodulatory effects, which help in reducing the symptoms and severity of the skin condition. The compound's ability to modulate the immune response and alleviate inflammation makes it a valuable asset in the management of psoriasis.
In addition to its use in the pharmaceutical industry, 4-(2-Thiazolylazo)resorcinol may also have potential applications in other fields, such as research and development, where it can be utilized for studying the mechanisms of various biological processes and the development of new therapeutic strategies. However, further research and development are necessary to fully understand and exploit its potential in these areas.

Purification Methods

Dissolve it in aqueous alkali, extract it with diethyl ether, and re-precipitate it with dilute HCl. The purity is checked by TLC on silica gel using pet ether/diethyl ether/EtOH (10:10:1) as the mobile phase. It complexes with Cu2+ (pH 3-4), Co2+ and Ni2+ (pH 7) and Zn2+ , andCd2+ (pH 8.4). [Beilstein 27 III/IV 5988.]

InChI:InChI=1/C9H7N3O2S/c13-6-1-2-7(8(14)5-6)11-12-9-10-3-4-15-9/h1-5,14H,(H,10,12)

Upstream product

• 96-50-4 2-thiazolylamine 
• 108-46-3 recorcinol 

Downstream Products

• 12301-13-2 Pb⁽²⁺⁾*CH₃CO₂^(1-)*C₉H₅N₃O₂S^(2-)*H⁽¹⁺⁾={Pb(CH₃CO₂)(C₉H₆N₃O₂S)} 
• 12300-69-5 Mn⁽²⁺⁾*C₉H₆N₃O₂S^(1-)*Cl^(1-)=Mn(C₉H₆N₃O₂S)Cl 

Relevant articles and documents

Thiazolylazo Dyes as Reagents for Detection and Ring Colorimetric Determination of Copper

Five thiazolylazo dyes namely 5-(2-thiazolylazo)-2,4-dihydroxybenzoic acid, 2-(2-thiazolylazo)-p-cresol, 1-(2-thiazolylazo)-2-naphthol, 4-(2-thiazolylazo)phloroglucinol and 4-(2-thiazolylazo)resorcinol have been found to be suitable reagents for the detection colorimetric determination of copper by ring oven technique. 1-(2-Thiazolylazo)-2-naphthol (TAN) has been found to be the most sensitive reagent.