224629-50-9Relevant articles and documents
Enantioselective Construction of Spiro Quaternary Carbon Stereocenters via Pd-Catalyzed Intramolecular α-Arylation
Wu, Ting,Kang, Xuehua,Bai, Heng,Xiong, Wenrui,Xu, Guangqing,Tang, Wenjun,Tang, Wenjun
supporting information, p. 4602 - 4607 (2020/06/29)
We herein report the development of a sterically hindered and electron-rich P-chiral monophosphorus biaryl ligand that has enabled a general and efficient enantioselective intramolecular α-arylation, providing access to a wide series of [4.4], [4.5], and [4.6]-spirocycles with chiral benzylic quaternary carbons in high yields with good to excellent enantioselectivities. A pronounced water effect on enantioselectivity is observed.
Syntheses of 3,4-benzotropolones by ring-closing metatheses
Arican, Deniz,Brückner, Reinhard
supporting information, p. 2582 - 2585 (2013/07/19)
Ortho-lithiated styrenes or ortho-lithiated benzaldehyde dimethyl acetals were added to 2,2-dimethoxypent-4-enals 7. The resulting alcohols were carried on to the aromatic dienones 10. These were ring-closed by olefin metathesis. Hydrolysis of the dimethyl ketal moiety and enolization provided the 3,4-benzotropolones 5. Overall, this access comprises 4-6 steps and totaled a 22-81% yield.
Oxygenated dihydrophenanthrenes via quinol acetals: A brief synthesis of orchinol
Broering, Teresa J.,Morrow, Gary W.
, p. 1135 - 1142 (2007/10/03)
The dihydrophenanthrene phytoalexin Orchinol was synthesized in 5 steps from commercially available 3,5-dimethoxybenzaldehyde. The approach utilized a new synthon, p-benzoquinone dibenzylmonoacetal, which served as a phenol 3,4-dication equivalent in an a
