2248-56-8

Basic information

• Product Name: ethyl 2-(4-fluorophenoxy)acetate
• Synonyms: ethyl 2-(4-fluorophenoxy)acetate
• CAS NO: 2248-56-8
• Molecular Weight: 198.194
• Mol File: 2248-56-8.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-fluorophenoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-fluorophenoxy)acetate(2248-56-8)
• EPA Substance Registry System: ethyl 2-(4-fluorophenoxy)acetate(2248-56-8)

Safety Data

• Hazardous Substances Data: 2248-56-8(Hazardous Substances Data)

Upstream product

• 367-12-4 2-fluorophenol 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 1052694-72-0 2-{[(2-fluorophenyl)oxy]acetyl}hydrazinecarbonylthioamide 
• 247128-21-8 5-{[(2-fluorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-amine 
• 1263183-68-1 C₁₃H₁₀FN₃O₂S 
• 380426-61-9 2-fluorophenoxyacetic acid hydrazide 
• 904702-74-5 O-methyl [(2-(2-fluorophenoxy)acetoxy)(2,4-dichlorophenyl)methyl]methylphosphinate 
• 904702-72-3 O-methyl [(2-(2-fluorophenoxy)acetoxy)(phenyl)methyl]methylphosphinate 
• 904702-71-2 O-methyl [(2-(2-fluorophenoxy)acetoxy)(4-methylphenyl)methyl]methylphosphinate 
• 904702-69-8 O-methyl [(2-(2-fluorophenoxy)acetoxy)(4-fluorophenyl)methyl]methylphosphinate 
• 904702-68-7 O-methyl [(2-(2-fluorophenoxy)acetoxy)(2-chlorophenyl)methyl]methylphosphinate 
• 1395103-28-2 2-(2-fluorophenoxyacetoxy)(phenyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1395103-23-7 2-[(2-fluorophenoxy)acetoxy](furan-2-yl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 449811-69-2 8-cyclopropyl-6-(2-fluorophenoxy)-2-(methylthio)-8H-pyrido[2,3-d]pyrimidin-7-one 
• 2965-17-5 <2-Fluor-phenoxy>-acetylchlorid 
• 348-10-7 (2-fluorophenoxy)acetic acid 

Relevant articles and documents

Synthesis, structure analysis, DFT calculations and energy frameworks of new coumarin appended oxadiazoles, to regress ascites malignancy by targeting VEGF mediated angiogenesis

Ascites malignancy is a frequent cause of morbidity and presents significant management problems which occur in many cancers. Angiogenesis plays a major role in the prognosis of ascites tumor through Vascular Endothelial Growth Factor (VEGF). Inhibition o

Synthesis, Nematicidal Activity, and 3D-QSAR of Novel 1,3,4-Oxadiazole/ Thiadiazole Thioether Derivatives

Forty one novel 1,3,4-oxadiazole/thiadiazole thioether derivatives containing phenoxy moiety were designed and synthesized. Bioassay demonstrated that some of them showed remarkable activities against Tylenchulus semipenetrans in vitro and in vivo. Compounds 20, 21, 35 and 39 showed excellent lethal activities after treatment for 48?h in vitro, with LC50 values of 13.4?±?1.8, 11.7?±?2.5, 13.7?±?2.4 and 13.3?±?1.1?mg·L–1, respectively, which were obviously superior to fosthiazate (49.1?±?2.8?mg·L–1) and avermectin (26.6?±?2.3?mg·L–1). Compound 21 can effectively control the citrus nematode disease caused by T. semipenetrans at 200?mg·L–1 in vivo with (68?±?3)% inhibitory effect, which was even better than that of avermectin ((63?±?2)%). The CoMFA and CoMSIA models of three-dimensional quantitative structure-activity relationships (3D-QSARs) were established. The compound 33 was designed based on the 3D-QSAR models with more vigorous nematicidal activities in vitro (LC50?=?9.8?±?1.4?mg·L–1) and in vivo ((70?±?5)%). These results demonstrated that compound 33 can be considered as a potential nematicide.

Synthesis and biological activity of 1-(Substituted phenoxyacetoxy)- 1-(pyridin-2-yl or thien-2-yl)methylphosphonates

A series of novel O,O-dimethyl 1-(substituted phenoxyacetoxy)-1-(pyridin-2-yl or thien-2-yl)methylphosphonates 6a-n and 7a-d were synthesized. Their structures were confirmed by IR, 1H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. For example, the title compounds 6a, 6c, 6l, 6m, and 7d possess 90-100% inhibition against most of the tested plants at the dosage of 1500 g ai/ha, whereas the title compounds 6b, 6g-h and 6n possess 92-100% inhibition against Fusarium oxysporum, Phyricularia grisea, Botrytis cinereapers, Gibberella zeae, Sclerotinia sclerotiorum, and Cercospora beticola at the concentration of 50mg/L.