224818-27-3Relevant articles and documents
POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
-
, (2018/05/24)
Disclosed herein are pyrido[3',2':4,5]thieno[2,3-d]pyridazin-8-amine and thieno[2,3-c:4,5-d']dipyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4).
Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors
Chappie, Thomas A.,Humphrey, John M.,Allen, Martin P.,Estep, Kimberly G.,Fox, Carol B.,Lebel, Lorraine A.,Liras, Spiros,Marr, Eric S.,Menniti, Frank S.,Pandit, Jayvardhan,Schmidt, Christopher J.,Tu, Meihua,Williams, Robert D.,Yang, Feng V.
, p. 182 - 185 (2007/10/03)
A papaverine based pharmacophore model for PDE10A inhibition was generated via SBDD and used to design a library of 4-amino-6,7-dimethoxyquinazolines. From this library emerged an aryl ether pyrrolidyl 6,7-dimethoxyquinazoline series that became the focal
Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application
-
, (2008/06/13)
The present invention provides compounds of the formula: wherein m is 0, 1 or 2; p is 0 or 1; Y is O, S, S(O) or S(O)2 and R1 to R7 are various substituents as selective modulators of the nicotinic acetylcholine receptor u