22504-02-5

Basic information

• Product Name: 2-CHLORO-N-(2-PHENOXY-PHENYL)-ACETAMIDE
• Synonyms: AKOS BBS-00003880;2-CHLORO-N-(2-PHENOXY-PHENYL)-ACETAMIDE
• CAS NO: 22504-02-5
• Molecular Formula: C₁₄H₁₂ClNO₂
• Molecular Weight: 261.7
• Mol File: 22504-02-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CHLORO-N-(2-PHENOXY-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-(2-PHENOXY-PHENYL)-ACETAMIDE(22504-02-5)
• EPA Substance Registry System: 2-CHLORO-N-(2-PHENOXY-PHENYL)-ACETAMIDE(22504-02-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 22504-02-5(Hazardous Substances Data)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 2688-84-8 2-phenoxyaniline 
• 88-73-3 2-Chloronitrobenzene 
• 108-95-2 phenol 

Downstream Products

• 1160748-16-2 2-azido-N-(2-phenoxy-phenyl)-acetamide 
• 1360180-49-9 N-((1-(2-oxo-2-(2-phenoxyphenylamino)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(3-oxobenzo[d]isothiazol-2(3H)-yl)acetamide 
• 1360180-68-2 N-(3-((1-(2-oxo-2-(2-phenoxyphenylamino)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-(3-oxobenzo[d]isothiazol-2(3H)-yl)acetamide 
• 445464-86-8 2-morpholin-4-yl-N-(2-phenoxyphenyl)acetamide 
• 1018598-19-0 N-(2-phenoxyphenyl)-2-piperazin-1-yl-acetamide 
• 1211620-95-9 2-(1H-Imidazol-1-yl)-N-(2-phenoxyphenyl)acetamide 
• 1352057-78-3 (1-{2-oxo-2-[(2-phenoxyphenyl)amino]ethyl}-1H-indol-3-yl)acetic acid 
• 1001625-83-7 2-(dimethylamino)-N-(2-phenoxyphenyl)acetamide 
• 109614-75-7 Diaethylamino-acetyl-(2-phenoxy-anilid) 
• 1352056-64-4 C₁₄H₁₅N₃O₂ 
• 64046-54-4 N,N-diethyl-glycine-(2-phenoxy-anilide); hydrochloride 

Relevant articles and documents

Thiazolidinedione "magic Bullets" Simultaneously Targeting PPARγand HDACs: Design, Synthesis, and Investigations of their in Vitro and in Vivo Antitumor Effects

Monotargeting anticancer agents suffer from resistance and target nonspecificity concerns, which can be tackled with a multitargeting approach. The combined treatment with HDAC inhibitors and PPARγagonists has displayed potential antitumor effects. Based on these observations, this work involves design and synthesis of molecules that can simultaneously target PPARγand HDAC. Several out of 25 compounds inhibited HDAC4, and six compounds acted as dual-targeting agents. Compound 7i was the most potent, with activity toward PPARγEC50 = 0.245 μM and HDAC4 IC50 = 1.1 μM. Additionally, compounds 7c and 7i were cytotoxic to CCRF-CEM cells (CC50 = 2.8 and 9.6 μM, respectively), induced apoptosis, and caused DNA fragmentation. Furthermore, compound 7c modulated the expression of c-Myc, cleaved caspase-3, and caused in vivo tumor regression in CCRF-CEM tumor xenografts. Thus, this study provides a basis for the rational design of dual/multitargeting agents that could be developed further as anticancer therapeutics.

Inhibition of dengue virus and west Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives

Two click chemistry-derived focused libraries based on the benz[d]isothiazol-3(2H)-one scaffold were synthesized and screened against Dengue virus and West Nile virus NS2B-NS3 proteases. Several compounds (4l, 7j-n) displayed noteworthy inhibitory activity toward Dengue virus NS2B-NS3 protease in the absence and presence of added detergent. These compounds could potentially serve as a launching pad for a hit-to-lead optimization campaign.