2252-62-2

Basic information

• Product Name: 4-(TRIFLUOROMETHYL)PHENYL DIMETHYL CARBINOL
• Synonyms: 4-(TRIFLUOROMETHYL)PHENYL DIMETHYL CARBINOL;2-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOL-2;2-(4-(TRIFLUOROMETHYL)PHENYL)-2-PROPANOL;1-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOL-2;4-(2-Hydroxyprop-2-yl)benzotrifluoride;2-[4-(TRIFLUOROMETHYL)PHENYL]PROPAN-2-OL;4-(2-Hydroxyprop-2-yl)benzotrifluoride 97%;4-(2-Hydroxyprop-2-yl)benzotrifluoride97%
• CAS NO: 2252-62-2
• Molecular Formula: C₁₀H₁₁F₃O
• Molecular Weight: 204.19
• Product Categories: Hydroxymethyl's;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 2252-62-2.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(TRIFLUOROMETHYL)PHENYL DIMETHYL CARBINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHYL)PHENYL DIMETHYL CARBINOL(2252-62-2)
• EPA Substance Registry System: 4-(TRIFLUOROMETHYL)PHENYL DIMETHYL CARBINOL(2252-62-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 2252-62-2(Hazardous Substances Data)

Usage

General Description

4-(Trifluoromethyl)phenyl dimethyl carbinol is a compound with the chemical formula C10H11F3O. It is a colorless liquid that is commonly used as a reagent in organic synthesis and in the production of pharmaceuticals. This chemical is known for its ability to act as a chiral auxiliary in stereoselective synthesis, and it has also been utilized in the preparation of various compounds with biological activity. Additionally, it has potential applications as a ligand in transition metal catalyzed reactions. Overall, 4-(Trifluoromethyl)phenyl dimethyl carbinol is a versatile compound with a range of uses in the fields of chemistry and pharmaceuticals.

Upstream product

• 2967-66-0 methyl 4-(trifluoromethyl)benzoate 
• 676-58-4 methylmagnesium chloride 
• 74-88-4 methyl iodide 
• 55186-75-9 4-trifluoromethyl-α-methylstyrene 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 106-93-4 ethylene dibromide 
• 32445-89-9 2-methyl-2-(4-(trifluoromethyl)phenyl)propanoic acid 
• 32445-87-7 2-methyl-2-(4-(trifluoromethyl)phenyl)propanenitrile 
• 32445-99-1 4-isopropyl-1-(trifluoromethyl)benzene 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 67-64-1 acetone 
• 583-02-8 ethyl 4-(trifluoromethyl)benzoate 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 32445-90-2 2-(p-Trifluoromethylphenyl)-2-methyl-propan-1-ol 

Downstream Products

• 2924-89-2 1-(α-chloro-isopropyl)-4-trifluoromethyl-benzene 
• 412048-34-1 tert-butyl 4-trifluoromethylcumyl peroxide 
• 178180-81-9 2-methyl-2-(4-(trifluoromethyl)phenyl)oxirane 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 32445-99-1 4-isopropyl-1-(trifluoromethyl)benzene 
• 36043-45-5 1-(1,2-Dibromo-1-methyl-ethyl)-4-trifluoromethyl-benzene 
• 306761-54-6 2-[4-(trifluoromethyl)phenyl]propan-2-amine 
• 412048-35-2 4-trifluoromethylcumyloxy radical 
• 52450-41-6 2-isopropyl-5-(trifluoromethyl)aniline 
• 52450-40-5 2-Nitro-4-(trifluormethyl)-1-(2-propyl)benzol 
• 52450-43-8 2-Hydroxy-4-(trifluormethyl)-1-(2-propyl)benzol 
• 13127-05-4 cis-1-trifluoromethyl-4-tert-butyl-cyclohexane 
• 13127-04-3 trans-1-trifluoromethyl-4-tert-butyl-cyclohexane 
• 99334-85-7 2-methoxy-2-(4'-(trifluoromethyl)phenyl)propane 

Relevant articles and documents

CALICHEAMICIN DERIVATIVES AND ANTIBODY DRUG CONJUGATES THEREOF

The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.

ARYL AND HETEROARYL ETHER COMPOUNDS AS ROR GAMMA MODULATORS

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, R, R2, R3, n, and p are as defined herein, which are active as modulators of retinoid-related orpha

Kinetics and mechanism of acid catalysed hydration of α- methylstyrenes

Twelve para-substituted α-methylstyrenes with substituents H, CH 3, CF3, CH3O, CH3S, F, Cl, Br, CH3CO, CH3SO2, CN a NO2 were synthesised; additionally, the acid catalysed hydration kinetics of these compounds were measured in sulfuric acid in a concentration range c from 0.017 to 9.58 mol l-1, at 25.0°C. The observed rate constants obtained were used to construct the kinetic acidity function and calculate the catalytic rate constants. Based on the evaluation of the acidity function kinetic dependence on acid medium concentration, and the substituent effects of acid catalysed hydration of α-methylstyrenes on the catalytic rate constants, the mechanism of acid catalysed hydration was verified. The mechanism involves the addition of a proton to the double bond of α-methylstyrene in the rate-limiting reaction step denoted as A-SE2. No evident difference was found between the effects of the acid medium on the acid catalysed hydration of styrenes and α-methylstyrenes, which indicates very similar activity coefficients of the reactants, and of the transition state of both substrates. The substituent effects evaluation shows that the rate-limiting step of the reaction consists in the addition of a proton to the substrate. The carbocation formation in the transition state of this reaction step proceeds roughly half-way compared with the extent of the carbocation formation by cumyl chloride hydrolysis. The obtained carbocation is in particular stabilised by the substituents with +M effect, while the influence of the substituents with -M and I effects is significantly smaller.