225526-26-1

Basic information

• Product Name: 2,2,2-trifluoro-1-(4-methoxy-2-(tetrahydropyran-2-yloxymethyl)phenyl)ethanol
• Synonyms: 2,2,2-trifluoro-1-(4-methoxy-2-(tetrahydropyran-2-yloxymethyl)phenyl)ethanol
• CAS NO: 225526-26-1
• Molecular Weight: 320.309
• Mol File: 225526-26-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-1-(4-methoxy-2-(tetrahydropyran-2-yloxymethyl)phenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-1-(4-methoxy-2-(tetrahydropyran-2-yloxymethyl)phenyl)ethanol(225526-26-1)
• EPA Substance Registry System: 2,2,2-trifluoro-1-(4-methoxy-2-(tetrahydropyran-2-yloxymethyl)phenyl)ethanol(225526-26-1)

Safety Data

• Hazardous Substances Data: 225526-26-1(Hazardous Substances Data)

Upstream product

• 225526-25-0 2-(2-bromo-5-methoxybenzyl)tetrahydro-2H-pyran 
• 460-40-2 3,3,3-trifluoropropanal 

Downstream Products

• 225526-27-2 2,2,2-trifluoro-1-(2-hydroxymethyl-4-methoxyphenyl)ethanol 

Relevant articles and documents

Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists

This invention provides a compound of the formula: and its pharmaceutically acceptable salts, wherein R1 is C1-C6 alkyl; R2 is hydrogen, C1-C6 alkyl, halo C1-C6 alkyl or phenyl; R3 is hydrogen or halo; R4 and R5 are independently hydrogen, C1-C6 alkyl or halo C1-C6 alkyl; and n is one, two or three. These compounds are useful as analgesics or anti-inflammatory agents, or in the treatment of cardiovascular diseases, allergic disorders, angiogenesis, CNS disorders, emesis, gastrointestinal disorders, sunburn, urinary incontinence, or diseases, disorders or adverse conditions caused by Helicobacter pylori, or the like, in a mammalian subject, especially humans. Intermediates for preparation of the compounds of Formula (I) are also disclosed.