22563-62-8

Basic information

• Product Name: (E)-3-(4-nitrophenyl)-1-(1H-pyrrol-2-yl)prop-2-en-1-one
• Synonyms: (E)-3-(4-nitrophenyl)-1-(1H-pyrrol-2-yl)prop-2-en-1-one
• CAS NO: 22563-62-8
• Molecular Weight: 242.234
• Mol File: 22563-62-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-3-(4-nitrophenyl)-1-(1H-pyrrol-2-yl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(4-nitrophenyl)-1-(1H-pyrrol-2-yl)prop-2-en-1-one(22563-62-8)
• EPA Substance Registry System: (E)-3-(4-nitrophenyl)-1-(1H-pyrrol-2-yl)prop-2-en-1-one(22563-62-8)

Safety Data

• Hazardous Substances Data: 22563-62-8(Hazardous Substances Data)

Upstream product

• 1072-83-9 2-Acetylpyrrole 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 76905-87-8 (Z)-3-(4-Nitro-phenyl)-1-(1H-pyrrol-2-yl)-propenone 

Relevant articles and documents

Preliminary insight of pyrrolylated-chalcones as new anti-methicillin-resistant staphylococcus aureus (Anti-mrsa) agents

Bacterial infections are regarded as one of the leading causes of fatal morbidity and death in patients infected with diseases. The ability of microorganisms, particularly methicillin-resistant Staphylococcus aureus (MRSA), to develop resistance to current drugs has evoked the need for a continuous search for new drugs with better efficacies. Hence, a series of non-PAINS associated pyrrolylated-chalcones (1–15) were synthesized and evaluated for their potency against MRSA. The hydroxyl-containing compounds (8, 9, and 10) showed the most significant anti-MRSA efficiency, with the MIC and MBC values ranging from 0.08 to 0.70 mg/mL and 0.16 to 1.88 mg/mL, respectively. The time-kill curve and SEM analyses exhibited bacterial cell death within four hours after exposure to 9, suggesting its bactericidal properties. Furthermore, the docking simulation between 9 and penicillin-binding protein 2a (PBP2a, PDB ID: 6Q9N) suggests a relatively similar bonding interaction to the standard drug with a binding affinity score of ?7.0 kcal/mol. Moreover, the zebrafish model showed no toxic effects in the normal embryonic development, blood vessel formation, and apoptosis when exposed to up to 40 μM of compound 9. The overall results suggest that the pyrrolylated-chalcones may be considered as a potential inhibitor in the design of new anti-MRSA agents.

Synthesis and biologic activities of some novel heterocyclic chalcone derivatives

We synthesized 36 chalcone-like (E)-3-(substitutedphenyl)-1-hetrylprop-2- en-1-ones by condensing 2-acetylfuran/2-acetylpyrrole with substituted benzaldehydes under basic conditions. Of the 36 molecules synthesized, 10 are new to the literature. Bio-evalu