2257-69-4

Basic information

• Product Name: 4-CHLORO-1,2-DIHYDROPHTHALAZIN-1-ONE
• Synonyms: AURORA KA-6768;4-CHLORO-1,2-DIHYDROPHTHALAZIN-1-ONE;1-Chlorophtalazin-4-one;1-CHLOROPHTHALAZIN-4-ONE;1-CHLORO-4-PHTHALAZINONE;4-Chloro-1(2H)-phthalazinone, 98%;1-Chloro-3,4-dihydrophthalazin-4-one;4-chlorophthalazin-1(2H)-one
• CAS NO: 2257-69-4
• Molecular Formula: C₈H₅ClN₂O
• Molecular Weight: 180.59
• Mol File: 2257-69-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 273 °C
• Boiling Point: 452.7 °C at 760 mmHg
• Flash Point: 227.6 °C
• Appearance: /
• Density: 1.5 g/cm³
• Vapor Pressure: 8.2E-09mmHg at 25°C
• Refractive Index: 1.688
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.58±0.40(Predicted)
• CAS DataBase Reference: 4-CHLORO-1,2-DIHYDROPHTHALAZIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-1,2-DIHYDROPHTHALAZIN-1-ONE(2257-69-4)
• EPA Substance Registry System: 4-CHLORO-1,2-DIHYDROPHTHALAZIN-1-ONE(2257-69-4)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 2257-69-4(Hazardous Substances Data)

Usage

Uses

1-Chlorophthalazin-4-one acts as an organic and pharmaceutical intermediate.

InChI:InChI=1/C8H5ClN2O/c9-7-5-3-1-2-4-6(5)8(12)11-10-7/h1-4H,(H,11,12)

Upstream product

• 7647-01-0 hydrogenchloride 
• 4752-10-7 1,4-dichlorophthalazine 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 85-44-9 phthalic anhydride 
• 4397-55-1 phthalic monoacid monomethyl ester chloride 
• 1875-48-5 N-aminophthalamide 
• 4388-29-8 [2,2'-biisoindoline]-1,1',3,3'-tetraone 
• 136918-14-4 phthalimide 
• 87878-22-6 2-phenyl-4-(2-methyl-4-chloro-1,2-dihydro-1-phthalazinylidene)benzohydrazidine 
• 88-99-3 benzene-1,2-dicarboxylic acid 

Downstream Products

• 78755-14-3 4-pyrrolidino-1-(2H)-phthalazinone 
• 69776-14-3 phthalazonyl glycol ether 
• 78755-15-4 4-piperidino-1(2H)-phthalazinone 
• 78755-24-5 4-octamethyleneimino-1(2H)-phthalazinone 

Relevant articles and documents

Discovery of Phthalazinone Derivatives as Novel Hepatitis B Virus Capsid Inhibitors

HBV capsid assembly has been viewed as an attractive target for new antiviral therapies against HBV. On the basis of a lead compound 4r, we further investigated this target to identify novel active compounds with appropriate anti-HBV potencies and improved pharmacokinetic (PK) properties. Structure-activity relationship studies based on metabolic pathways of 4r led to the identification of a phthalazinone derivative 19f with appropriate anti-HBV potencies (IC50 = 0.014 ± 0.004 μM in vitro), which demonstrated high oral bioavailability and liver exposure. In the AAV-HBV/mouse model, administration of 19f resulted in a 2.67 log reduction of the HBV DNA viral load during a 4-week treatment with 150 mg/kg dosing twice daily.

Phthalazinone compound and preparation method, pharmaceutical composition and use thereof

The invention relates to a phthalazinone compound and a preparation, pharmaceutical composition and use thereof, wherein the structure of the phthalazinone compound is shown as formula one, and the compound of the formula one is targeted to a virus nuclea

TOLL-LIKE RECEPTOR 8 (TLR8)-SPECIFIC ANTAGONISTS AND METHODS OF MAKING AND USES THEREOF

Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.