22591-21-5Relevant articles and documents
Method for preparing alpha,alpha-dichloroketone under solvent-free condition
-
Page/Page column 7-8, (2021/06/21)
The invention provides a method for synthesizing an alpha,alpha-dichloroketone compound by taking methyl ketone and sulfonyl chloride as raw materials. The method comprises the following steps: heating a reaction mixture of methyl ketone and sulfonyl chloride to 80 DEG C under a dry air condition, stirring for 4-8 hours, after the reaction is finished, removing sulfonyl chloride from the obtained mixture, and carrying out silica gel column chromatography separation by taking ethyl acetate-hexane as an eluent to obtain the alpha,alpha-dichloroketone compound. The synthesis method provided by the invention has the advantages of extremely high chemical reactivity and selectivity, simple and easily available raw materials, low price, simple operation, no need of any catalyst and solvent, reduction of the synthesis cost and the pollution of organic solvents to the environment, greenness, economy and the like.
H2O2/HCl system: Oxidation-chlorination of secondary alcohols to α,α′-dichloro ketones
Nikishin, Gennady I.,Kapustina, Nadezhda I.,Sokova, Lyubov' L.,Bityukov, Oleg V.,Terent'ev, Alexander O.
supporting information, (2020/07/13)
The one-pot oxidation-chlorination of secondary alcohols to give α,α′-dichloro ketones in 62–80percent yields is reported. The convenient and readily available H2O2/HCl system acts on secondary alcohols (C5-C17) with the formation of α,α′-dichloro ketones. The reaction proceeds with high selectivity under the reported conditions; during this process peroxide formation and the Baeyer-Villiger oxidation reactions are not observed.
Production process of dichloro pinacolone (by machine translation)
-
Paragraph 0011, (2020/12/29)
The production process is characterized in that the specific production process is as follows: S1: 2 - Chloropentane preparation. S2: pinacolone. S3: pinacolone rectification. S4: synthesis of dichloro-pinacolone. S5: treatment of by-products. In addition, by adopting formaldehyde addition in the chlorination reaction, the reaction rate 3 times or more can be inhibited, and reaction and cooling can be completed between a general reaction requirement 70 - 75 hours by adding formaldehyde, and cooling by adopting chilled water, so that the production efficiency is greatly improved 20 - 25 hours. (by machine translation)