22601-06-5

Basic information

• Product Name: 3-METHYLFURAN-2-CARBONYL CHLORIDE
• Synonyms: 3-METHYL-2-FUROYL CHLORIDE;3-METHYLFURAN-2-CARBONYL CHLORIDE;3-METHYLFURAN-2-CARBONYLCHLORIDE,97%;2-METHYLFURAN-2-CARBONYL CHLORIDE 97%;2-Furancarbonyl chloride, 3-Methyl-
• CAS NO: 22601-06-5
• Molecular Formula: C₆H₅ClO₂
• Molecular Weight: 144.56
• Product Categories: API intermediates
• Mol File: 22601-06-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 77-78°C 12mm
• Flash Point: 88°C
• Appearance: /
• Density: 1.263
• Vapor Pressure: 0.54mmHg at 25°C
• Refractive Index: 1.5325
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-METHYLFURAN-2-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLFURAN-2-CARBONYL CHLORIDE(22601-06-5)
• EPA Substance Registry System: 3-METHYLFURAN-2-CARBONYL CHLORIDE(22601-06-5)

Safety Data

• Hazard Codes: Xi
• Statements: 34-36
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• WGK Germany: 3
• Hazardous Substances Data: 22601-06-5(Hazardous Substances Data)

Usage

General Description

3-Methylfuran-2-carbonyl chloride is a chemical compound with the molecular formula C6H5ClO2. It is a reactive and powerful acylating agent that is used in various organic synthesis processes. The compound is a colorless to light yellow liquid with a pungent odor, and it is highly flammable. It is primarily used as an intermediate in the production of pharmaceutical products and agrochemicals. 3-METHYLFURAN-2-CARBONYL CHLORIDE is known to be hazardous and should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system upon exposure.

InChI:InChI=1/C6H5ClO2/c1-4-2-3-9-5(4)6(7)8/h2-3H,1H3

Upstream product

• 4412-96-8 3-methylfuran-2-carboxylic acid 
• 6141-57-7 methyl 3-methylfuran-2-carboxylate 
• 33342-48-2 3-methyl-2-furfuraldehyde 
• 930-27-8 3-methylfuran 
• 38435-37-9 ethyl 3-methyl furan-2-carboxylate 

Downstream Products

• 6141-57-7 methyl 3-methylfuran-2-carboxylate 
• 56776-63-7 3-methyl-furan-2-carboxylic acid anilide 

Relevant articles and documents

-

-

The synthesis of (-)-cis- and (-)-trans-crobarbatic acid

The synthesis of both cis- and trans-crobarbatic acid is reported. The five-step sequence proceeds in high yield and with control of both relative and absolute stereochemistry. The key step in the synthesis is the Birch reductive alkylation of a chiral furoic acid which sets the absolute stereochemistry of the products. The stereochemistry of the compounds described was proven unambiguously by X-ray crystallography on one synthetic intermediate and on trans-crobarbatic acid.

Palladium-Catalyzed Enantioselective Intramolecular Dearomative Heck Reaction

Enantioselective intramolecular dearomative Heck reactions have been developed by Pd-catalyzed cross-coupling of aryl halides or aryl triflates with the internal C=C bond of indoles, benzofurans, pyrroles, and furans. A variety of structurally unique spir

Conformational effects in diastereoselective aryne diels-alder reactions: synthesis of benzo-fused [2.2.1] heterobicycles

It was found that the diastereoselectivity of the Dials-Alder reaction between arynes and substituted furans Is highly sensitive to substitution, which affects the reactive conformation. By varying the location of the groups on the diene partner, It Is po

Kinase Inhibitors

The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.