22604-07-5

Basic information

• Product Name: 1-Naphthalenol,6-methoxy-
• Synonyms: 1-Naphthol,6-methoxy- (6CI,7CI,8CI);1-Hydroxy-6-methoxynaphthalene;6-Methoxy-1-naphthol;6-Methoxynaphthalen-1-ol
• CAS NO: 22604-07-5
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.1959
• EINECS: 200-589-5
• Mol File: 22604-07-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 85 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 336.678 °C at 760 mmHg
• Flash Point: 211.849 °C
• Appearance: /
• Density: 1.193 g/cm³
• Vapor Pressure: 5.65E-05mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.26±0.40(Predicted)
• CAS DataBase Reference: 1-Naphthalenol,6-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Naphthalenol,6-methoxy-(22604-07-5)
• EPA Substance Registry System: 1-Naphthalenol,6-methoxy-(22604-07-5)

Safety Data

• Hazardous Substances Data: 22604-07-5(Hazardous Substances Data)

Usage

General Description

"1-Naphthalenol, 6-methoxy-" or better known as Thymol blue, is a pH indicator. It is a brownish-green or brownish-blue crystalline powder and is one of the chemicals that is typically used in laboratories and various scientific researches. The indicator changes color in the pH range of 1.2 to 2.8 (red) and 8.0 to 9.6 (blue). This chemical is soluble in ethanol and ether, slightly soluble in water, but insoluble in benzene and petroleum ether. Thymol blue is believed to be harmless if used in small amounts but could cause harm if ingested or if it comes in contact with skin in large quantities. As per the Globally Harmonized System (GHS) of Classification and Labeling of Chemicals, it is categorized as a substance that causes severe eye damage.

InChI:InChI=1/C11H10O2/c1-13-9-5-6-10-8(7-9)3-2-4-11(10)12/h2-7,12H,1H3

Upstream product

• 69769-74-0 4,6-dimethoxy-1-naphthylbenzyl ketone 
• 1258740-26-9 (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid 
• 1258740-24-7 (R)-3-(benzyloxycarbonylamino)-4-(3-methoxyphenyl)butanoic acid 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 42200-95-3 4,6-dimethoxy-1-naphthylmethyl ketone 
• 67-56-1 methanol 
• 575-44-0 1,6-dihydroxynaphthalene 

Downstream Products

• 35697-10-0 5-hydroxy-2-tetralone 

Relevant articles and documents

Synthesis of substituted (S)-2-aminotetralins via ring-opening of aziridines prepared from l-aspartic acid β-tert-butyl ester

This paper describes the total synthesis of the hydrochloride salts of (2S)-2-amino-7-methoxytetralin (21-HCl) and (2S)-2-amino-6-fluoro-7- methoxytetralin (ST1214), from a common enantiomerically pure aziridine 4b, which was available from l-aspartic acid β-tert-butyl ester. The synthesis of 21-HCl and ST1214 proceeded in nine steps and 5 and 6% overall yields, respectively. Key steps are the regioselective ring-opening of 4b with ArMgBr/CuBr·SMe2 and the intramolecular Friedel-Crafts cyclisation providing α-tetralone. Substituted naphthalenes were formed as side products in the latter reaction.

N-1H-tetrazol-5-yl-2-naphthalene carboxamides and their use as antiallergy and antiinflammatory agents

Novel naphthalene derivatives having antiallergy and antiinflammatory activity.