226225-42-9 Usage
Description
(2S,4R)-N-tert-butyloxycarbonyl-4-[(tert-butyldiphenylsilyl)oxy]pyrrolidine-2-carboxylic acid methyl ester is a complex organic molecule characterized by a pyrrolidine ring structure, which consists of four carbon atoms and one nitrogen atom. (2S,4R)-N-tert-butyloxycarbonyl-4-[(tert-butyldiphenylsilyl)oxy]pyrrolidine-2-carboxylic acid methyl ester features a tert-butyloxycarbonyl (Boc) group, a tert-butyldiphenylsilyl (TBDPS) group, and a methyl ester group. The Boc group serves as a protective group for amines, while the TBDPS group is utilized for the protection of hydroxyl groups. The methyl ester group is a carboxylic acid derivative, commonly employed in organic synthesis. (2S,4R)-N-tert-butyloxycarbonyl-4-[(tert-butyldiphenylsilyl)oxy]pyrrolidine-2-carboxylic acid methyl ester holds potential applications in organic chemistry and pharmaceutical research due to its capacity for selective functional group transformations and as a building block for more intricate molecular structures.
Uses
Used in Organic Chemistry:
(2S,4R)-N-tert-butyloxycarbonyl-4-[(tert-butyldiphenylsilyl)oxy]pyrrolidine-2-carboxylic acid methyl ester is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure and functional groups allow for selective reactions and transformations, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (2S,4R)-N-tert-butyloxycarbonyl-4-[(tert-butyldiphenylsilyl)oxy]pyrrolidine-2-carboxylic acid methyl ester is used as a building block for the development of new drugs. Its potential for selective functional group modifications and its structural features make it a promising candidate for the creation of novel therapeutic agents with specific biological activities.
Used in Protecting Group Chemistry:
(2S,4R)-N-tert-butyloxycarbonyl-4-[(tert-butyldiphenylsilyl)oxy]pyrrolidine-2-carboxylic acid methyl ester is used as a protecting agent for amines and hydroxyl groups during organic synthesis. The Boc and TBDPS groups provide temporary protection to these functional groups, allowing for selective reactions to occur at other sites on the molecule, which can be crucial for the successful synthesis of complex organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 226225-42-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,2,2 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 226225-42:
(8*2)+(7*2)+(6*6)+(5*2)+(4*2)+(3*5)+(2*4)+(1*2)=109
109 % 10 = 9
So 226225-42-9 is a valid CAS Registry Number.
226225-42-9Relevant articles and documents
KRAS G12D INHIBITORS
-
Paragraph 0961, (2021/03/05)
The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
POLYMYXIN ANALOGS USEFUL AS ANTIBIOTIC POTENTIATORS
-
Paragraph 0185, (2017/12/09)
The disclosure provides compounds of the formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt of either of the foregoing. The variables A, R1, and R2 are defined in the disclosure. The disclosure further includes pharmaceutical compositions comprising a compound of formula I together with at least one pharmaceutically acceptable carrier. The disclosure also includes a method of sensitizing bacteria to an antibacterial agent, comprising administering to a patient infected with the bacteria, simultaneously or sequentially, a therapeutically effective amount of the antibacterial agent and a compound of formula (I).
Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines as EGFR and ErbB-2 inhibitors
Stevens, Kirk L.,Alligood, Krystal J.,Alberti, Jennifer G. Badiang,Caferro, Thomas R.,Chamberlain, Stanley D.,Dickerson, Scott H.,Dickson, Hamilton D.,Emerson, Holly K.,Griffin, Robert J.,Hubbard, Robert D.,Keith, Barry R.,Mullin, Robert J.,Petrov, Kimberly G.,Gerding, Roseanne M.,Reno, Michael J.,Rheault, Tara R.,Rusnak, David W.,Sammond, Douglas M.,Smith, Stephon C.,Uehling, David E.,Waterson, Alex G.,Wood, Edgar R.
scheme or table, p. 21 - 26 (2009/04/10)
A novel class of pyrrolidinyl-acetyleneic thieno[3,2-d]pyrimidines has been identified which potently inhibit the EGFR and ErbB-2 receptor tyrosine kinases. Synthetic modifications of the pyrrolidine carbamate moiety result in a range of effects on enzyme and cellular potency. In addition, the impact of the absolute stereochemical configuration on cellular potency and oral mouse pharmacokinetics is described.
