22628-62-2Relevant articles and documents
A short and efficient synthesis of (+)-totarol
Rogachev, Victor,Loehl, Thorsten,Markert, Thomas,Metz, Peter
, p. 172 - 180 (2013/09/24)
A concise route to multigram quantities of the antibacterial diterpene (+)-totarol (1) is reported. (-)-Sclareol (2) was converted to the target compound 1 using either a six- or a seven-step sequence, while only three steps were required to access (+)-totarol ( 1) starting from (+)-manool (9) or (+)-13-epi-manool (10), respectively. A novel one-pot intramolecular aldol condensation/α-alkylation protocol served as the key operation for streamlining the syntheses of 1. ARKAT-USA, Inc.