226878-01-9 Usage
Description
NPS 2390 is a first-generation quinoxaline derivative that serves as a noncompetitive antagonist of metabotropic glutamate receptors (mGluR1 and mGluR5) with IC50 values of 5.2 and 82 nM, respectively. It is of interest for the treatment of various central nervous system (CNS) disorders, such as pain, epilepsy, and stroke, due to its selective action on mGluR1 and mGluR5 without affecting other receptors, ion channels, and enzymes.
Uses
Used in Pharmaceutical Industry:
NPS 2390 is used as a therapeutic agent for the treatment of CNS disorders such as pain, epilepsy, and stroke. It acts as a noncompetitive antagonist of mGluR1 and mGluR5, modulating excitatory synaptic transmission in the central nervous system.
Used in Research Applications:
NPS 2390 is used as a research tool for studying the role of mGluR1 and mGluR5 in various CNS disorders. Its selective action allows for a better understanding of the underlying mechanisms and potential therapeutic targets.
Used in Drug Development:
NPS 2390 is used as a lead compound in the development of novel therapeutics for the treatment of CNS disorders. Its potent and selective antagonistic properties make it a valuable starting point for designing new drugs with improved efficacy and safety profiles.
Used in Calcium-sensing Receptor (CaSR) Inhibition:
NPS 2390 is used as an inhibitor of CaSR, which can lead to the up-regulation of anti-apoptotic protein Bcl-2 expression and down-regulation of pro-apoptotic protein Bax. This application may have potential implications in the treatment of conditions related to apoptosis and calcium signaling.
Check Digit Verification of cas no
The CAS Registry Mumber 226878-01-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,8,7 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 226878-01:
(8*2)+(7*2)+(6*6)+(5*8)+(4*7)+(3*8)+(2*0)+(1*1)=159
159 % 10 = 9
So 226878-01-9 is a valid CAS Registry Number.
226878-01-9Relevant articles and documents
Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
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, (2008/06/13)
The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
