22700-44-3

Basic information

• Product Name: diethyl (4-methoxyphenyl)phosphoramidate
• CAS NO: 22700-44-3
• Molecular Formula: C₁₁H₁₈NO₄P
• Molecular Weight: 259.2387
• Mol File: 22700-44-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 330.9°C at 760 mmHg
• Flash Point: 153.9°C
• Density: 1.182g/cm³
• Vapor Pressure: 0.000162mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: diethyl (4-methoxyphenyl)phosphoramidate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (4-methoxyphenyl)phosphoramidate(22700-44-3)
• EPA Substance Registry System: diethyl (4-methoxyphenyl)phosphoramidate(22700-44-3)

Safety Data

• Hazardous Substances Data: 22700-44-3(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 122-52-1 triethyl phosphite 
• 762-04-9 Diethyl phosphonate 
• 762-04-9 phosphonic acid diethyl ester 
• 90-04-0 2-methoxy-phenylamine 
• 6374-26-1 diethyl phosphorisothiocyanatidate 
• 814-49-3 diethyl chlorophosphate 
• 18714-09-5 N--imidophosphorsaeure-triethylester 
• 25626-97-5 Ethyl-(4-methoxy-phenyl)-phosphoramidic acid diethyl ester 
• 100-17-4 para-methoxynitrobenzene 
• 22303-36-2 N-(4-methoxyphenyl)-2-chloroacetamide 
• 5470-34-8 4-methoxyformanilide 

Downstream Products

• 1387601-46-8 C₂₂H₂₁NO 
• 1266570-29-9 diethyl 3,3-bis(4-chlorophenyl)-1-phenylpropa-1,2-dienyl(4-methoxyphenyl)phosphoramidate 
• 1266570-46-0 1,3-bis(4-bromophenyl)-2-(4-methoxyphenyl)-4,9,9-triphenyl-4,9-dihydro-2H-benzo[f]isoindol-4-ol 
• 1266570-28-8 diethyl 3,3-bis(4-methoxyphenyl)-1-phenylpropa-1,2-dienyl(4-methoxyphenyl)phosphoramidate 
• 1266570-32-4 diethyl 2-(9H-fluoren-9-ylidene)-1-phenylvinyl(4-methoxyphenyl)phosphoramidate 
• 1266570-44-8 2-(4-methoxyphenyl)-4,9,9-triphenyl-1,3-di-p-tolyl-4,9-dihydro-2H-benzo[f]isoindol-4-ol 
• 1266570-40-4 2-(4-methoxyphenyl)-1,3,4,9,9-pentaphenyl-4,9-dihydro-2H-benzo[f]isoindol-4-ol 
• 1266570-21-1 diethyl 4-methoxyphenyl(1,3,3-triphenylpropa-1,2-dienyl)phosphoramidate 
• 1266570-26-6 diethyl 1-(4-ethylphenyl)-3,3-diphenylpropa-1,2-dienyl(4-methoxyphenyl)phosphoramidate 
• 20265-97-8 p-anisidine hydrochloride 
• 122845-64-1 cyclohexanecarbaldehyde N-4-methoxyphenylimine 
• 122845-63-0 N-(4-Methoxyphenyl)-3-methylbutanaldimine 
• 55560-24-2 C₁₉H₃₀NO₇P 

Relevant articles and documents

Reinvestigation of the iodine-mediated phosphoramidation reaction of amines and P(OR)3 and its synthetic applications

A systematic study on the iodine-mediated phosphoramidation reaction of amines and trialkyl phosphites was conducted, which not only disclosed the factors affecting the reaction but also revealed that it could proceed smoothly in CH2Cl2 at room temperature in open air. Using this method, various phosphoramidates with different aliphatic amines and aromatic amines were synthesized in good to excellent yields. Our present investigation shows that this underused method is actually a mild, practical and general way to synthesize phosphoramidates and will have wide applications.

Fe3O4@MgO nanoparticles as an efficient recyclable catalyst for the synthesis of phosphoroamidates via the Atherton-Todd reaction Dedicated to Professor Tsutomu Yokomatsu from Tokyo University of Pharmacy and Life Sciences on the occasion of his 65th birthday

A simple and efficient method is presented for the synthesis of phosphoroamidates in moderate to good yield via the Atherton-Todd coupling of primary amines with H-dialkyl phosphites using Fe3O4@MgO nanoparticles as a recyclable catalyst.

Phosphoramidate synthesis via copper-catalysed aerobic oxidative coupling of amines and H-phosphonates

The copper-catalysed oxidative coupling of amines and H-phosphonates to produce phosphoramidates has been achieved using CuI as the catalyst and O 2 (present in air) as the sole oxidant.