22794-26-9

Basic information

• Product Name: dodecyl 5-oxo-L-prolinate
• Synonyms: dodecyl 5-oxo-L-prolinate;LAURYL PCA;L-Proline, 5-oxo-, dodecyl ester;(S)-5-Oxopyrrolidine-2-carboxylic acid dodecyl ester;Pyroglutamic acid dodecyl ester;Einecs 245-224-1
• CAS NO: 22794-26-9
• Molecular Formula: C₁₇H₃₁NO₃
• Molecular Weight: 297.43294
• EINECS: 245-224-1
• Mol File: 22794-26-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 437.8°C at 760 mmHg
• Flash Point: 218.6°C
• Appearance: /
• Density: 0.99g/cm³
• Vapor Pressure: 7.28E-08mmHg at 25°C
• Refractive Index: 1.47
• PKA: 14?+-.0.40(Predicted)
• CAS DataBase Reference: dodecyl 5-oxo-L-prolinate(CAS DataBase Reference)
• NIST Chemistry Reference: dodecyl 5-oxo-L-prolinate(22794-26-9)
• EPA Substance Registry System: dodecyl 5-oxo-L-prolinate(22794-26-9)

Safety Data

• Hazardous Substances Data: 22794-26-9(Hazardous Substances Data)

Usage

Description

Dodecyl 5-oxo-L-prolinate is a lipophilic emulsifier derived from natural raw materials, known for its good affinity with skin lipids. It possesses moisturizing properties and a delayed, remnant effect, making it a valuable ingredient in the cosmetic and personal care industry.

Uses

Used in Cosmetics and Personal Care Industry:
Dodecyl 5-oxo-L-prolinate is used as an emulsifier for its ability to effectively blend oil and water components in cosmetic formulations. Its affinity with skin lipids allows for better absorption and improved moisturizing action, which can be attributed to its capacity to decrease transepidermal water loss.
Additionally, dodecyl 5-oxo-L-prolinate is used as a lipophilic moisturizer for its delayed and remnant effect, providing long-lasting hydration to the skin.
Furthermore, dodecyl 5-oxo-L-prolinate is utilized as a thickener or viscosity-control agent, enhancing the texture and stability of various cosmetic and personal care products. Its natural origin makes it a preferred choice for formulations that emphasize eco-friendly and sustainable ingredients.

InChI:InChI=1/C17H31NO3/c1-2-3-4-5-6-7-8-9-10-11-14-21-17(20)15-12-13-16(19)18-15/h15H,2-14H2,1H3,(H,18,19)/t15-/m0/s1

Upstream product

• 112-53-8 1-dodecyl alcohol 
• 98-79-3 L-Pyroglutamic acid 

Relevant articles and documents

Cosmetic composition

A composition suitable for topical application to mammalian skin and hair for inducing, maintaining or increasing hair growth comprises a hair growth promoter chosen from glutamine derivatives and salts thereof. The composition preferably also comprises an activity enhancer which may be chosen from hair growth stimulants, penetration enhancers and cationic polymers.

Cosmetic composition containing DOPA derivatives

A composition for topical application to human hair or skin contains a chemical analogue of dihydroxyphenyl alanine (DOPA). This chemical analogue can be absorbed by skin or by a hair follicle and metabolised in-vivo, thus leading to the formation of melanin in skin or to the growth of melanin-pigmented hair. Consequently the composition can give controlled skin darkening to mimic sun-induced tanning or can bring about the growth of dar hair in place of the grey or white hair.

Cosmetic composition

A composition suitable for topical application to mammalian skin or hair for inducing, maintaining or increasing hair growth comprises: (i) a first chemical inhibitor chosen from proteoglycanase inhibitors, glycosaminoglycanase inhibitors, glycosaminoglycan chain cellular uptake inhibitors or mixtures thereof; and (ii) a cosmetically acceptable vehicle for the chemical inhibitor; provided that when the first chemical inhibitor is a weak inhibitor, such that a 1 mM aqueous solution of the inhibitor reduces proteoglycanase activity, glycosaminoglycanase activity or cellular uptake of glycosaminoglycan chains, by from 5 to 50%, in accordance with at least one of the assay tests as herein described, then there is also present in the composition a second chemical inhibitor and/or an activity enhancer. When minoxidil is the sole chemical inhibitor, then the activity enhancer is a penetration enhancer chosen from a limited number of materials, including certain esters and cationic polymers. The total amount of chemical inhibitor present in the composition is sufficient to increase hair growth in the rat, when said composition is applied topically thereto, by at least 10% more than that obtainable using a control composition from which the said inhibitors have been omitted.