22801-59-8

Basic information

• Product Name: 3-(morpholin-4-yl)-1,2-benzoisothiazole
• Synonyms: 3-(morpholin-4-yl)-1,2-benzoisothiazole
• CAS NO: 22801-59-8
• Molecular Weight: 220.295
• Mol File: 22801-59-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(morpholin-4-yl)-1,2-benzoisothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(morpholin-4-yl)-1,2-benzoisothiazole(22801-59-8)
• EPA Substance Registry System: 3-(morpholin-4-yl)-1,2-benzoisothiazole(22801-59-8)

Safety Data

• Hazardous Substances Data: 22801-59-8(Hazardous Substances Data)

Upstream product

• 30165-96-9 3-Morpholino-4-chloro-1,2,5-thiadiazole 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Relevant articles and documents

An Aryne-Based Route to Substituted Benzoisothiazoles

The combination of arynes, generated using fluoride from the corresponding 2-(trimethylsilyl)aryl triflates, and 3-hydroxy-4-aminothiadiazoles leads to the selective formation of 3-amino-substituted benzo[d]isothiazoles. Variation of the substitution pattern of the aryne precursor, and of the thiadiazole, is possible, with the target heterocycles being obtained in good to excellent yields. In all cases, use of 3-hydroxy-4-aminothiadiazoles leads to incorporation of the amino-substituent in the product heterocycle.