22821-89-2

Basic information

• Product Name: 1,3-dichloro-5-(methylsulphonyl)benzene
• Synonyms: 1,3-dichloro-5-(methylsulphonyl)benzene;3,4-DICHLOROPHENYLMETHYLSULPHONE;1,3-Dichloro-5-(methylsulfonyl)benzene;Benzene, 1,3-dichloro-5-(methylsulfonyl)-;Einecs 245-250-3
• CAS NO: 22821-89-2
• Molecular Formula: C₇H₆Cl₂O₂S
• Molecular Weight: 225.09234
• EINECS: 245-250-3
• Product Categories: Boron, Nitrile, Thio,& TM-Cpds
• Mol File: 22821-89-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 382.8 °C at 760 mmHg
• Flash Point: 185.3 °C
• Appearance: /
• Density: 1.451 g/cm³
• Vapor Pressure: 1.02E-05mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 1,3-dichloro-5-(methylsulphonyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dichloro-5-(methylsulphonyl)benzene(22821-89-2)
• EPA Substance Registry System: 1,3-dichloro-5-(methylsulphonyl)benzene(22821-89-2)

Safety Data

• Hazardous Substances Data: 22821-89-2(Hazardous Substances Data)

Usage

General Description

1,3-dichloro-5-(methylsulphonyl)benzene is an organic compound with the chemical formula C7H6Cl2O2S. It is a white solid with a distinct odor and is primarily used in the production of pharmaceuticals, agrochemicals, and other fine chemicals. The compound is known for its strong insecticidal and acaricidal properties and is often used in the manufacture of veterinary drugs and pesticide formulations. It is also used as an intermediate in the synthesis of various organic compounds, and as a reagent in chemical reactions. However, it is important to handle this chemical with caution as it is toxic and harmful if swallowed, inhaled, or if it comes into contact with the skin.

InChI:InChI=1/C7H6Cl2O2S/c1-12(10,11)7-3-5(8)2-6(9)4-7/h2-4H,1H3

Upstream product

• 868-85-9 Dimethyl phosphite 
• 5470-49-5 4-methanesulfonylphenylamine 
• 80866-96-2 2,6-dichloro-4-(methylsulfonyl)aniline 
• 68121-46-0 (3,5-dichlorophenyl)(methyl)sulfane 

Relevant articles and documents

High Chemoselectivity in the Construction of Aryl Methyl Sulfones via an Unexpected C-S Bond Formation between Sulfonylhydrazides and Dimethyl Phosphite

A highly chemoselective route to aryl methyl sulfones via an unexpected C S bond formation between sulfonylhydrazides and dimethyl phosphite catalyzed by NaI under mild conditions has been established. This transformation provides an alternative and metal-free pathway to acquire various aryl methyl sulfones in good to excellent yields. Notably, dimethyl phosphite was employed as a stable and readily available alkyl source.

Flow Electrosynthesis of Sulfoxides, Sulfones, and Sulfoximines without Supporting Electrolytes

An efficient electrochemical flow process for the selective oxidation of sulfides to sulfoxides and sulfones and of sulfoxides toN-cyanosulfoximines has been developed. In total, 69 examples of sulfoxides, sulfones, andN-cyanosulfoximines have been synthesized in good to excellent yields and with high current efficiencies. The synthesis was assisted and facilitated through a supporting electrolyte-free, fully automated electrochemical protocol that highlights the advantages of flow electrolysis.