228266-40-8

Basic information

• Product Name: TANDUTINIB
• Synonyms: N,beta,beta-Trimethyl-L-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-butenyl]-N,3-dimethyl-L-valinamide;Taltobulin;Hti 286;L-Valinamide, N,beta,beta-trimethyl-L-phenylalanyl-N-((1S,2E)-3-carboxy-1-(1-methylethyl)-2-butenyl)-N,3-dimethyl-;Spa 110;Unii-J6D6912bxs;N,β,β-Trimethyl-L-phenylalanyl-N-[(3S,4E)-5-carboxy-2-methyl-4-hexen-3-yl]-N,3-dimethyl-L-valinamide;Taltobulin (HTI-286)
• CAS NO: 228266-40-8
• Molecular Formula: C27H31Br2ClN4O2
• Molecular Weight: 473.65
• Mol File: 228266-40-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 135-137 ºC
• Boiling Point: 662.4 °C at 760 mmHg
• Flash Point: 354.4 °C
• Appearance: /
• Density: 1.063
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 4.68±0.19(Predicted)
• CAS DataBase Reference: TANDUTINIB(CAS DataBase Reference)
• NIST Chemistry Reference: TANDUTINIB(228266-40-8)
• EPA Substance Registry System: TANDUTINIB(228266-40-8)

Safety Data

• Hazardous Substances Data: 228266-40-8(Hazardous Substances Data)

Upstream product

• 676629-67-7 N-{1-[(1-formyl-2-methyl-propyl)-methyl-carbamoyl]-2,2-dimethyl-propyl}-3-methyl-2-methylamino-3-phenyl-butyramide 

Relevant articles and documents

Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies

The stereochemistry of the tubulin inhibitors taltobulin HTI-286 (2) and HTI-042 (3) was determined by utilizing the DPFGSE 1D NOE experiment. Single crystal X-ray diffraction analysis further confirmed the absolute configuration of these two compounds, w