229027-94-5

Basic information

• Product Name: {5-Fluoro-2-[2-(triisopropylsilyl)ethyn-1-yl]phenyl}methanol
• Synonyms: {5-Fluoro-2-[2-(triisopropylsilyl)ethyn-1-yl]phenyl}methanol
• CAS NO: 229027-94-5
• Molecular Weight: 306.496
• Mol File: 229027-94-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {5-Fluoro-2-[2-(triisopropylsilyl)ethyn-1-yl]phenyl}methanol(CAS DataBase Reference)
• NIST Chemistry Reference: {5-Fluoro-2-[2-(triisopropylsilyl)ethyn-1-yl]phenyl}methanol(229027-94-5)
• EPA Substance Registry System: {5-Fluoro-2-[2-(triisopropylsilyl)ethyn-1-yl]phenyl}methanol(229027-94-5)

Safety Data

• Hazardous Substances Data: 229027-94-5(Hazardous Substances Data)

Upstream product

• 89343-06-6 tris-iso-propylsilyl acetylene 
• 202865-66-5 2-bromo-5-fluorobenzyl alcohol 
• 452-63-1 2-Bromo-5-fluorotoluene 
• 112399-50-5 2-bromo-5-fluorobenzyl bromide 

Downstream Products

• 286376-19-0 {2-[2-(4-Fluoro-2-hydroxymethylphenyl)ethyn-1-yl]phenyl}methanol 
• 229028-01-7 (2-Ethynyl-5-fluorophenyl)methanol 

Relevant articles and documents

Coupling reactions of ortho-substituted halobenzenes with alkynes. The synthesis of phenylacetylenes and symmetrical or unsymmetrical 1,2-diphenylacetylenes

The Pd- or Pd/Cu-catalyzed coupling reactions of halobenzenes bearing the methyl, hydroxymethyl, acetoxymethyl, methoxycarbonyl, or both methoxy and 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl groups in the ortho-position with gaseous or metallated acetylene, (trialkylsilyl)acetylenes, and arylacetylenes have been systematically studied. Various functionalized aryl- or diarylacetylenes have been synthesized in good to excellent yields. Whereas additional fluoro, nitro, or methoxy group attached to the benzene ring does not interfere in the coupling reactions, the presence of a methoxycarbonyl requires a careful optimization of reaction conditions to achieve moderate yields.