22913-11-7

Basic information

• Product Name: 4-Chlorobenzoic acid isopropyl ester
• Synonyms: 4-Chlorobenzoic acid 1-methylethyl ester;4-Chlorobenzoic acid isopropyl ester
• CAS NO: 22913-11-7
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 0
• Mol File: 22913-11-7.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Chlorobenzoic acid isopropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chlorobenzoic acid isopropyl ester(22913-11-7)
• EPA Substance Registry System: 4-Chlorobenzoic acid isopropyl ester(22913-11-7)

Safety Data

• Hazardous Substances Data: 22913-11-7(Hazardous Substances Data)

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 201230-82-2 carbon monoxide 
• 67-63-0 isopropyl alcohol 
• 75-26-3 isopropyl bromide 
• 74-11-3 para-chlorobenzoic acid 
• 195062-61-4 4-chlorophenylboronic acid pinacol ester 
• 108-20-3 di-isopropyl ether 
• 122-01-0 4-chloro-benzoyl chloride 
• 106-47-8 4-chloro-aniline 
• 21961-55-7 benzoic-p-chlorobenzoic anhydride 
• 140-53-4 p-chlorobenzyl cyanide 
• 996-35-0 N,N-dimethylisopropyl amine 
• 827605-29-8 2-(4-chloro-phenyl)-5,5-dimethyl-[1,3,2]dioxaborinane 
• 98-60-2 4-chlorobenzenesulfonyl chloride 

Downstream Products

• 104-88-1 4-chlorobenzaldehyde 
• 321-37-9 4'-chloro-2,2,2-trifluoroacetophenone 
• 1028206-87-2 C₁₄H₁₉NO₃ 
• 2928-09-8 isopropyl 4-fluorobenzoate 
• 7693-30-3 4-chlorobenzyl phenyl sulfide 

Relevant articles and documents

Metal-free radical aromatic carbonylations mediated by weak bases

We report a new method of metal-free alkoxycarbonylation. This reaction involves the generation of aryl radicals from arenediazonium salts by a very weak base (HCO2Na) under mild conditions. Subsequent radical trapping with carbon monoxide and alcohols gives alkyl benzoates. The conditions (metal-free, 1 equiv. base, MeCN, r.t., 3 h) tolerate various functional groups (I, Br, Cl, CF3, SF5, NO2, ester). Mechanistic studies indicate the operation of a radical aromatic substitution mechanism.

Acylative cleavage of ethers with ZnCl2

Acylative cleavage of common ether solvents with ZnCl2 was reported. Different substituted acyl chlorides were reacted with the common ether solvents in the presence of ZnCl2 to obtain the corresponding substituted benzoate.

Rhenium complex-catalyzed acylative cleavage of ethers with acyl chlorides

It was found that rhenium complex was an efficient catalyst for the acylative cleavage of C-O bond of ethers with acyl chlorides. When acyclic ethers were allowed to react with acyl chlorides in the presence of a catalytic amount of ReBr(CO)5, acylative cleavage of C-O bond of acyclic ethers smoothly proceeded to give the corresponding esters in moderate to good yields. Similarly, cyclic ethers were acylative cleaved by acyl chlorides to give the corresponding chloro substituted esters in good yields by the use of Re 2O7 catalyst.