22961-45-1

Basic information

• Product Name: 4-(PHENYLAMINO)PYRIDINE
• Synonyms: 4-ANILINOPYRIDINE;4-PYRIDINAMINE, N-PHENYL-;4-(PHENYLAMINO)PYRIDINE;AKOS BC-0724;N-phenylpyridin-4-amine;N-(4-Pyridyl)aniline;N-phenyl-4-pyridinamine;phenyl-(4-pyridyl)amine
• CAS NO: 22961-45-1
• Molecular Formula: C₁₁H₁₀N₂
• Molecular Weight: 170.21
• EINECS: 245-352-8
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines
• Mol File: 22961-45-1.mol
• Article Data: 24

Chemical Properties

• Melting Point: 177 °C
• Boiling Point: 324 °C at 760 mmHg
• Flash Point: 149.8 °C
• Appearance: /
• Density: 1.144 g/cm³
• Vapor Pressure: 0.000252mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 6.90±0.10(Predicted)
• CAS DataBase Reference: 4-(PHENYLAMINO)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PHENYLAMINO)PYRIDINE(22961-45-1)
• EPA Substance Registry System: 4-(PHENYLAMINO)PYRIDINE(22961-45-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 22961-45-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H10N2/c1-2-4-10(5-3-1)13-11-6-8-12-9-7-11/h1-9H,(H,12,13)

Upstream product

• 626-61-9 4-Chloropyridine 
• 62-53-3 aniline 
• 1121-76-2 4-chloropyridine N-oxide 
• 4783-86-2 4-phenoxypyridine 
• 33399-48-3 4-(phenylthio)pyridine 
• 3881-38-7 1-(4'-pyridyl)-4-pyridone 
• 142-04-1 aniline hydrochloride 
• 5421-92-1 1-(4-pyridyl)pyridinium chloride hydrochloride 
• 504-24-5 4-aminopyridine 
• 108-86-1 bromobenzene 
• 139-66-2 diphenyl sulfide 
• 945-51-7 1,1'-sulfinylbisbenzene 
• 620-08-6 4-methoxypyridine 
• 143-66-8 sodium tetraphenyl borate 

Downstream Products

• 73333-84-3 N-Phenyl-N-(4-pyridinyl)benzamide 
• 115891-63-9 1-(4-pyridyl)-3-n-butyl-4-hydroxy-2(1H)-quinolone 
• 115891-61-7 1-phenyl-3-n-butyl-1,6-naphthyridin-2(1H)-one 
• 261-90-5 10H-pyrido<3,4-b><1,4>benzothiazine 
• 172780-12-0 1-[4-(4-pyridylamino)phenyl]-2-chloropropanone 
• 1374852-36-4 cyanomethyl phenyl(pyridin-4-yl)carbamodithioate 

Relevant articles and documents

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Synthesis method of aza-arylamine compound and aza-arylamine compound

The invention provides a synthesis method of an aza-arylamine compound as shown in a formula (I). The synthesis method comprises the following steps: an aza aromatic hydrocarbon compound as shown in aformula (II) reacts with an amine compound as shown in a formula (III) in presence of alkali and under a heating condition, so that u X substituent groups on an A ring of the compound as shown in theformula (II) are substituted by NRR in the compound as shown in the formula (III), and the compound as shown in the formula (I) is obtained, wherein A is an aza six-membered aromatic ring or five-membered aromatic ring, and is an independent single ring or is fused with a ring B; X refers to that the A ring has at least n X substituent groups, each X substituent group is independently selected from the group consisting of F, Cl, Br, I, CN, alkoxy of C and alkylthio of C, and n is a positive integer selected from 1-5; and the alkali is one or a mixture of more selected fromof BuOK, BuONa, BuONa, KHMDS, NaHMDS and LiHMDS. The synthesis method provided by the invention does not need the use of transition metal catalysts, is simple and convenient to operate, is economical and practical and is environmentally friendly. In addition, the invention also provides the aza-arylamine compound prepared by the method.

Copper-Catalyzed NaBAr 4-Based N-Arylation of Amines

Using NaBAr 4 as an arylating agent, the formation of carbon-heteroatom bonds by a Cham-Lam cross-coupling reaction in the presence of catalytic copper(II) acetate monohydrate in acetonitrile at room temperature under air is described. The investigation of reaction scope suggests that several aliphatic and aromatic amines are compatible. In particular, the reaction of alkylamine and NaBAr 4 proceeds smoothly to offer the corresponding products in good to excellent yields.