22972-63-0Relevant articles and documents
Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists
Jiang, Shan,Iliopoulos-Tsoutsouvas, Christos,Tong, Fei,Brust, Christina A.,Keenan, Catherine M.,Raghav, Jimit Girish,Hua, Tian,Wu, Simiao,Ho, Jo-Hao,Wu, Yiran,Grim, Travis W.,Zvonok, Nikolai,Thakur, Ganesh A.,Liu, Zhi-Jie,Sharkey, Keith A.,Bohn, Laura M.,Nikas, Spyros P.,Makriyannis, Alexandros
, p. 3870 - 3884 (2021/05/04)
We report the development of novel cannabinergic probes that can stabilize the cannabinoid receptors (CBRs) through tight binding interactions. Ligand design involves the introduction of select groups at a judiciously chosen position within the classical
CANNABINOIDS AND USES THEREOF
-
Page/Page column 82-83, (2019/12/25)
The invention relates to cannabinoid compounds, pharmaceutical compositions including one or more cannabinoid compounds, and the use of pharmaceutical compositions including one or more cannabinoid compounds for the treatment of a disease or condition (e.
Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers
Zanato, Chiara,Pelagalli, Alessia,Marwick, Katie F. M.,Piras, Monica,Dall'Angelo, Sergio,Spinaci, Andrea,Pertwee, Roger G.,Wyllie, David J. A.,Hardingham, Giles E.,Zanda, Matteo
, p. 2086 - 2096 (2017/03/11)
We report the synthesis of terminally fluorinated HU-210 and HU-211 analogues (HU-210F and HU-211F, respectively) and their biological evaluation as ligands of cannabinoid receptors (CB1 and CB2) and N-methyl d-aspartate receptor (NMDAR). [18F]-labelled HU-210F was radiosynthesised from the bromo-substituted precursor. In vitro assays showed that both HU-210F and HU-211F retain the potent pharmacological profile of HU-210 and HU-211, suggesting that [18F]-radiolabelled HU-210F and HU-211F could have potential as PET tracers for in vivo imaging.