22979-35-7

Basic information

• Product Name: Benzeneacetic acid, a-diazo-, methyl ester
• CAS NO: 22979-35-7
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.175
• Mol File: 22979-35-7.mol
• Article Data: 127

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, a-diazo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, a-diazo-, methyl ester(22979-35-7)
• EPA Substance Registry System: Benzeneacetic acid, a-diazo-, methyl ester(22979-35-7)

Safety Data

• Hazardous Substances Data: 22979-35-7(Hazardous Substances Data)

Upstream product

• 1334313-47-1 (Z)-methyl 2-phenyl-2-(2-tosylhydrazono)acetate 
• 101-41-7 benzeneacetic acid methyl ester 
• 24461-61-8 phenylglycine methyl ester 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 941-55-9 4-toluenesulfonyl azide 
• 122-79-2 Phenyl acetate 
• 18793-81-2 methyl 2-phenyl-2-(2-tosylhydrazono)acetate 
• 71-43-2 benzene 
• 16648-44-5 methyl α-acetylphenylacetate 
• 54108-62-2 3-Oxo-2,3-diphenylpropenoic acid methyl ester 
• 121-44-8 triethylamine 
• 19883-41-1 D-phenylglycine methyl ester hydrochloride 
• 103-82-2 phenylacetic acid 
• 2158-14-7 4-acetamidobenzenesulfonyl azide 

Downstream Products

• 172945-17-4 phenyldiazoacetic acid 
• 218792-64-4 [(3S,6S,8S,8aS)-8-Benzyloxy-5-oxo-3-((2R,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxymethyl)-octahydro-indolizin-6-yloxy]-phenyl-acetic acid methyl ester 
• 13027-73-1 methyl 2-cyclohexyl-2-phenylacetate 

Relevant articles and documents

Efficient synthesis of chiral cyclic acetals by metal and Bronsted acid co-catalyzed enantioselective four-component cascade reactions

Four-component Mannich reactions subsequently followed by an intramolecular oxo-Michael addition were developed to efficiently produce chiral cyclic acetals with high diastereoselectivity and enantioselectivity. The Royal Society of Chemistry.

Palladium-Catalyzed Migratory Insertion of Carbenes and C-C Cleavage of Cycloalkanecarboxamides

A palladium catalyzed reaction of cycloalkanecarboxamides and diazomalonates or bis(phenylsulfonyl)diazomethane has been developed. The reaction proceeds via carbene migratory insertion and cascade C-C cleavage pathways. Cycloalkanecarboxamides with four to seven membered rings are applicable in the transformation. A series of ring opening products were prepared with moderate yields. The finding provides valuable clues for the development of new reactions involving carbene migratory insertion and the cleavage of unstrained C(sp3)-C(sp3) bonds.

Copper-Catalyzed Regioselective Coupling of Tosylhydrazones and 2-Pyridones: A Strategy for the Production of N-Alkylated Compounds

The highly regioselective N-alkylation reaction of 2-pyridones was achieved through hydrazone chemistry, especially for substrates with bulky secondary alkyl groups. Described herein is a copper-catalyzed coupling reaction of pyridone derivatives with tosylhydrazones.

B(C6F5)3-catalyzed O-H insertion reactions of diazoalkanes with phosphinic acids

A highly efficient base-, metal-, and oxidant-free catalytic O-H insertion reaction of diazoalkanes and phosphinic acids in the presence of B(C6F5)3has been developed. This powerful methodology provides a green approach towards the synthesis of a broad spectrum of α-phosphoryloxy carbonyl compounds with good to excellent yields (up to 99% yield). The protocol features the advantages of operational simplicity, high atom economy, practicality, easy scalability and environmental friendliness.