2301866-59-9 Usage
Description
N-3-pyridyl-N’-(1-[3-chloro-4-2-chloro-4-(trifluoromethoxy)phenoxypyridine-2-yl]piperidin-4-yl)thiourea is a complex organic compound characterized by its unique molecular structure. It is a derivative of thiourea, featuring a pyridine ring and a piperidine ring connected through a urea bridge. The molecule also contains a chlorinated phenoxy group and a trifluoromethoxy group, which may contribute to its specific properties and potential applications.
Uses
1. Used in Pharmaceutical Industry:
N-3-pyridyl-N’-(1-[3-chloro-4-2-chloro-4-(trifluoromethoxy)phenoxypyridine-2-yl]piperidin-4-yl)thiourea is used as a potent inhibitor of ABHD12 (α/β-hydrolase domain-containing 12) for its high specificity and negligible interaction with other serine hydrolases. This makes it a valuable compound for the development of targeted therapies and potential treatments for various diseases.
2. Used in Research Applications:
In the field of research, this compound can be utilized as a tool to study the role of ABHD12 in cellular processes and its potential involvement in disease pathways. By inhibiting ABHD12, researchers can gain insights into the enzyme's function and its impact on cellular mechanisms.
3. Used in Drug Development:
N-3-pyridyl-N’-(1-[3-chloro-4-2-chloro-4-(trifluoromethoxy)phenoxypyridine-2-yl]piperidin-4-yl)thiourea may serve as a lead compound in the development of new drugs targeting ABHD12-related diseases. Its high specificity and potency make it an attractive candidate for further optimization and modification to improve its pharmacological properties.
4. Used in Cellular and Molecular Biology:
N-3-pyridyl-N’-(1-[3-chloro-4-2-chloro-4-(trifluoromethoxy)phenoxypyridine-2-yl]piperidin-4-yl)thiourea can be employed in cellular and molecular biology experiments to investigate the effects of ABHD12 inhibition on cell signaling, metabolism, and other cellular processes. It can help researchers understand the role of ABHD12 in various biological pathways and its potential as a therapeutic target.
References
1) Ogasawara?et al.?(2019),?Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase α/β-Hydrolase Domain-Containing 12 (ABHD12); J. Med. Chem.,?62?1643
2) Ogasawara?et al.?(2018),?Selective Blockade of the Lyso-PS Lipase ABHD12 Stimulates Immune Responses In Vivo; Nat. Chem. Biol.,?14?1099
Check Digit Verification of cas no
The CAS Registry Mumber 2301866-59-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,3,0,1,8,6 and 6 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2301866-59:
(9*2)+(8*3)+(7*0)+(6*1)+(5*8)+(4*6)+(3*6)+(2*5)+(1*9)=149
149 % 10 = 9
So 2301866-59-9 is a valid CAS Registry Number.
2301866-59-9Relevant articles and documents
ABHD12 INHIBITORS AND METHODS OF MAKING AND USING SAME
-
Paragraph 00119; 00128, (2019/12/04)
Provided herein are compounds and compositions useful as modulators of ABHD12. Furthermore, the subject compounds and compositions are useful as immunotherapies in treating, for instance, cancer or infectious diseases.
