230295-16-6

Basic information

• Product Name: 4-Trifluoromethyl-3-fluorobenzyl alcohol
• Synonyms: 3-Fluoro-4-(trifluoromethyl)benzenemethanol;2-Fluoro-4-(hydroxymethyl)benzotrifluoride, [3-Fluoro-4-(trifluoromethyl)phenyl]methanol;3-Fluoro-4-(trifluoromethyl)benzylalcohol97%;(3-Fluoro-4-(trifluoromethyl)phenyl)methanol
• CAS NO: 230295-16-6
• Molecular Formula: C₈H₆F₄O
• Molecular Weight: 194.13
• Product Categories: Fluorine series
• Mol File: 230295-16-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 28-32°C
• Boiling Point: 209℃
• Flash Point: 80℃
• Appearance: /
• Density: 1.377
• Vapor Pressure: 0.128mmHg at 25°C
• Refractive Index: 1.447
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.76±0.10(Predicted)
• CAS DataBase Reference: 4-Trifluoromethyl-3-fluorobenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Trifluoromethyl-3-fluorobenzyl alcohol(230295-16-6)
• EPA Substance Registry System: 4-Trifluoromethyl-3-fluorobenzyl alcohol(230295-16-6)

Safety Data

• Hazardous Substances Data: 230295-16-6(Hazardous Substances Data)

Usage

General Description

4-Trifluoromethyl-3-fluorobenzyl alcohol is a chemical compound with the molecular formula C8H6F4O. It is a white crystalline solid that is commonly used in organic synthesis and as a building block in the production of pharmaceuticals and agrochemicals. 4-Trifluoromethyl-3-fluorobenzyl alcohol is known for its unique properties, including its ability to act as a chiral auxiliary in asymmetric synthesis reactions. It is also used as a reagent in the synthesis of various organic compounds due to its versatile reactivity. Additionally, 4-Trifluoromethyl-3-fluorobenzyl alcohol has potential applications in the development of new materials and in medicinal chemistry research.

InChI:InChI=1/C8H6F4O/c9-7-3-5(4-13)1-2-6(7)8(10,11)12/h1-3,13H,4H2

Upstream product

• 773873-89-5 methyl 3-fluoro-4-(trifluoromethyl)benzoate 
• 204339-72-0 3-fluoro-4-trifluoromethyl-benzaldehyde 
• 115754-21-7 3-fluoro-4-(trifluoromethyl)benzoic acid 

Downstream Products

• 1610416-86-8 2-fluoro-4-(methoxymethyl)-1-(trifluoromethyl)benzene 
• 1610415-41-2 1-(1',4-dimethyl-1-phenyl-1H,1'H-[3,4'-bipyrazol]-5-yl)-3-(5-(methoxymethyl)-2-(trifluoromethyl)benzyl)urea 
• 1610416-87-9 5-(methoxymethyl)-2-(trifluoromethyl)benzonitrile 
• 1610416-88-0 (5-(methoxymethyl)-2-(trifluoromethyl)phenyl)methanamine 
• 1621222-25-0 (R)-6-((1-cyclobutylethyl)amino)-7-(3-fluoro-4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile 
• 1621222-27-2 (R)-2-chloro-N-(1-cyclobutylethyl)-7-(3-fluoro-4-(trifluoromethyl)benzyl)-7H-purin-6-amine 
• 1621222-26-1 2,6-dichloro-7-(3-fluoro-4-(trifluoromethyl)benzyl)-7H-purine 
• 213203-65-7 4-(bromomethyl)-2-fluoro-1-(trifluoromethyl)benzene 
• 444915-54-2 4-(chloromethyl)-2-fluoro-1-(trifluoromethyl)benzene 
• 478373-37-4 {4'-methoxy-3'-[(3-fluoro-4-trifluoromethyl-benzyloxycarbonylamino)methyl]biphenyl-3yl}acetic acid 
• 478373-87-4 2-{4'-Methoxy-3'-[(3-fluoro-4-trifluoromethylbenzyloxycarbonylamino)methyl]biphenyl-3-yl}propionic acid 
• 478373-57-8 {4'-Ethoxy-3'-[(3-fluoro-4-trifluoromethylbenzyloxycarbonylamino)methyl]biphenyl-3-yl}-acetic acid 

Relevant articles and documents

Design, Synthesis, and in vitro Evaluation of P2X7 Antagonists

The P2X7 receptor is a promising target for the treatment of various diseases due to its significant role in inflammation and immune cell signaling. This work describes the design, synthesis, and in vitro evaluation of a series of novel derivatives bearing diverse scaffolds as potent P2X7 antagonists. Our approach was based on structural modifications of reported (adamantan-1-yl)methylbenzamides able to inhibit the receptor activation. The adamantane moieties and the amide bond were replaced, and the replacements were evaluated by a ligand-based pharmacophore model. The antagonistic potency of the synthesized analogues was assessed by two-electrode voltage clamp experiments, using Xenopus laevis oocytes that express the human P2X7 receptor. SAR studies suggested that the replacement of the adamantane ring by an aryl-cyclohexyl moiety afforded the most potent antagonists against the activation of the P2X7 cation channel, with analogue 2-chloro-N-[1-(3-(nitrooxymethyl)phenyl)cyclohexyl)methyl]benzamide (56) exhibiting the best potency with an IC50 value of 0.39 μΜ.

2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS

The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions compris

AMINOETHANOL DERIVATIVES

The present invention provides a pharmaceutical agent having cholesteryl ester transfer protein inhibitory action and useful as a blood lipid lowering agent and the like. The present invention relates to a compound represented by the formula wherein Ar1 is an aromatic ring group optionally having substituents, Ar2 is an aromatic ring group having substituents, OR'' is an optionally protected hydroxyl group, R is an acyl group, R' is a hydrogen atom or a hydrocarbon group optionally having substituents, or a salt thereof, and a pharmaceutical composition containing a compound of the formula (I) or a salt thereof or a prodrug thereof.