2304-58-7

Basic information

• Product Name: 5-CyanopentanaMide
• Synonyms: 5-CyanopentanaMide
• CAS NO: 2304-58-7
• Molecular Formula: C₆H₁₀N₂O
• Molecular Weight: 126.1564
• Product Categories: Amines, Miscellaneous Reagents
• Mol File: 2304-58-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 66-67 °C
• Boiling Point: 175-195 °C(Press: 3 Torr)
• Appearance: /
• Density: 1.036±0.06 g/cm3(Predicted)
• PKA: 16.48±0.40(Predicted)
• CAS DataBase Reference: 5-CyanopentanaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CyanopentanaMide(2304-58-7)
• EPA Substance Registry System: 5-CyanopentanaMide(2304-58-7)

Safety Data

• Hazardous Substances Data: 2304-58-7(Hazardous Substances Data)

Usage

Description

5-Cyanopentanamide, also known as adiponitrile hydration product, is an organic compound derived from adiponitrile, which is a dinitrile. It serves as a crucial precursor in the production of the polymer nylon 66. 5-CyanopentanaMide is characterized by its cyano group and amide functionality, which contribute to its unique chemical properties and potential applications.

Uses

Used in Polymer Industry:
5-Cyanopentanamide is used as a monomer for the production of nylon 66, a widely used synthetic polymer known for its strength, durability, and resistance to various environmental factors. The compound plays a vital role in the polymerization process, leading to the formation of the polymer chains that make up nylon 66.
Used in Chemical Synthesis:
5-Cyanopentanamide can be utilized as a building block in the synthesis of various other organic compounds and materials. Its unique structure allows for further chemical modifications and reactions, making it a versatile starting material for the development of new chemicals with potential applications in various industries.
Used in Pharmaceutical Industry:
Due to its structural similarity to certain biologically active molecules, 5-Cyanopentanamide may have potential applications in the pharmaceutical industry as a starting material for the development of new drugs. Its reactivity and functional groups can be exploited to design and synthesize novel drug candidates with potential therapeutic properties.
Used in Research and Development:
5-Cyanopentanamide can be employed as a research tool in various scientific studies, particularly in the fields of polymer science, organic chemistry, and materials science. Its unique properties and reactivity make it an interesting compound for exploring new reaction pathways, understanding molecular interactions, and developing innovative materials and applications.

Upstream product

• 111-69-3 hexanedinitrile 
• 628-94-4 adipamide 

Downstream Products

• 105-60-2 caprolactam 
• 373-04-6 6-aminocaproic amide 
• 68049-71-8 2-(2,4-dichloro-5-hydroxyphenyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-A]pyridin-3(2H)-one 
• 68049-83-2 azafenidin 

Relevant articles and documents

5-Cyanovaleramide production using immobilized Pseudomonas chlororaphis B23

A biocatalytic process for the hydration of adiponitrile to 5- cyanovaleramide has been developed which can be run to higher conversion, produces more product per weight of catalyst, and generates significantly less waste products than alternate chemical processes. The biocatalyst consists of Pseudomonas chlororaphis B23 microbial cells immobilized in calcium alginate beads. The cells contain a nitrile hydratase (EC 4.2.1.84) which catalyzes the hydration of adiponitrile to 5-cyanovaleramide with high regioselectivity, and with less than 5% selectivity to byproduct adipamide. Fifty-eight consecutive batch reactions with biocatalyst recycle were run to convert a total of 12.7 metric tons of adiponitrile to 5-cyanovaleramide. At 97% adiponitrile conversion, the yield of 5-cyanovaleramide was 13.6 metric tons (93% yield, 96% selectivity), and the total weight of 5-cyanovaleramide produced per weight of catalyst was 3150 kg/kg (dry cell weight).

Hydration of nitriles using a metal-ligand cooperative ruthenium pincer catalyst

Nitrile hydration provides access to amides that are important structural elements in organic chemistry. Here we report catalytic nitrile hydration using ruthenium catalysts based on a pincer scaffold with a dearomatized pyridine backbone. These complexes catalyze the nucleophilic addition of H2O to a wide variety of aliphatic and (hetero)aromatic nitriles in tBuOH as solvent. Reactions occur under mild conditions (room temperature) in the absence of additives. A mechanism for nitrile hydration is proposed that is initiated by metal-ligand cooperative binding of the nitrile.

A heterogeneous catalytic method for the conversion of nitriles into amides using molecular sieves modified with copper(II)

A heterogenous catalytic method is developed for the hydration of nitriles into amides with acetaldoxime. Copper(II) supported on 4 molecular sieves is an efficient catalyst for this reaction.