23056-47-5 Usage
Description
2-Bromo-5-nitro-4-picoline is an organic compound characterized by its bromine and nitro functional groups attached to a picoline (pyridine) ring. It is a versatile intermediate in the synthesis of various pharmaceuticals and chemical compounds due to its unique structural features.
Uses
Used in Pharmaceutical Industry:
2-Bromo-5-nitro-4-picoline is used as a synthetic intermediate for the development of novel therapeutic agents. Its unique structure allows for the creation of new drugs with potential applications in various medical fields.
Used in HIV Treatment:
2-Bromo-5-nitro-4-picoline is used as a reagent in the synthetic preparation of azaindole hydroxamic acid, which are potent HIV-1 integrase inhibitors. These inhibitors play a crucial role in the development of antiretroviral drugs, helping to combat the HIV virus and manage the progression of the disease.
Used in Cancer Research:
The compound is also utilized in the discovery of 3,5-substituted 6-azaindazoles, which are potent pan-Pim inhibitors. Pim kinases are known to be overexpressed in various types of cancer, and their inhibition can potentially lead to the development of new cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 23056-47-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,0,5 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 23056-47:
(7*2)+(6*3)+(5*0)+(4*5)+(3*6)+(2*4)+(1*7)=85
85 % 10 = 5
So 23056-47-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H5BrN2O2/c1-4-2-6(7)8-3-5(4)9(10)11/h2-3H,1H3
23056-47-5Relevant articles and documents
PLASMA KALLIKREIN INHIBITORS AND USES THEREOF
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Paragraph 0999; 1000, (2021/03/19)
The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors
Plewe, Michael B.,Butler, Scott L.,Dress, Klaus R.,Hu, Qiyue,Johnson, Ted W.,Kuehler, Jon E.,Kuki, Atsuo,Lam, Hieu,Liu, Wen,Nowlin, Dawn,Peng, Qinghai,Rahavendran, Sadayappan V.,Tanis, Steven P.,Tran, Khanh T.,Wang, Hai,Yang, Anle,Zhang, Junhu
experimental part, p. 7211 - 7219 (2010/06/13)
HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and is essential for viral replication. Recently, HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Herein, we report the discovery of azaindole carboxylic aci
PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE
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Page 39, (2008/06/13)
Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.