23097-85-0

Basic information

• Product Name: 1H-Pyrazole-5-carboxylic acid, 1-methyl-4-phenyl-, methyl ester
• CAS NO: 23097-85-0
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.239
• Mol File: 23097-85-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-5-carboxylic acid, 1-methyl-4-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-5-carboxylic acid, 1-methyl-4-phenyl-, methyl ester(23097-85-0)
• EPA Substance Registry System: 1H-Pyrazole-5-carboxylic acid, 1-methyl-4-phenyl-, methyl ester(23097-85-0)

Safety Data

• Hazardous Substances Data: 23097-85-0(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 5932-28-5 4-phenyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 81190-89-8 methyl 4-bromo-1H-pyrazole-3-carboxylate 
• 84547-84-2 4-bromo-2-methyl-2H-pyrazole-3-carboxylic acid 
• 514816-42-3 4-bromo-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 98-80-6 phenylboronic acid 
• 13257-30-2 (E)-N-benzoyldidehydrophenylalanine methyl ester 
• 21462-02-2 methyl (Z)-2-benzoylamino-3-phenyl-2-propenoate 
• 60676-51-9 methyl (Z)-2-(acetylamino)-3-phenylpropenoate 
• 142598-53-6 2-methyl-4-phenyl-2H-pyrazole-3-carboxylic acid 
• 637-44-5 phenylpropyolic acid 

Downstream Products

• 1396006-74-8 2-methyl-4-phenyl-2H-pyrazol-3-yl-carbamic acid (R)-1-phenyl-ethyl ester 
• 142598-53-6 2-methyl-4-phenyl-2H-pyrazole-3-carboxylic acid 

Relevant articles and documents

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts

Lysophosphatidic acid is a class of bioactive phospholipid that mediates most of its biological effects through LPA receptors, of which six isoforms have been identified. The recent results from LPA1 knockout mice suggested that blocking LPA1 signaling could provide a potential novel approach for the treatment of idiopathic pulmonary fibrosis. Here, we report the design and synthesis of pyrazole- and triazole-derived carbamates as LPA1-selective and LPA1/3 dual antagonists. In particular, compound 2, the most selective LPA1 antagonist reported, inhibited proliferation and contraction of normal human lung fibroblasts (NHLF) following LPA stimulation. Oral dosing of compound 2 to mice resulted in a dose-dependent reduction of plasma histamine levels in a murine LPA challenge model. Furthermore, we applied our novel antagonists as chemistry probes and investigated the contribution of LPA1/2/3 in mediating the pro-fibrotic responses. Our results suggest LPA1 as the major receptor subtype mediating LPA-induced proliferation and contraction of NHLF.

Studies on Organic Fluorine Compounds. XLII. Synthesis and Reactions of Phenyltrifluoromethylacetylenes

Phenyltrifluoromethylacetylene (4a) was synthesized by the pyrolysis of triphenylphosphonium α-(trifluoroacetyl)benzylide (3a), which was easily derived from benzyl halide (1a).This method can be used for the synthesis of 4-substituted-phenyltrifluoromethylacetylenes (4).The 1,3-dipolar reaction of 4 with diazomethane and phenyl azide proceeds readily to give trifluoromethylated pyrazoles and triazoles.Keywords - trifluoromethyl; acetylene; 1,3-dipolar reaction; intramolecular Wittig reaction; trifluoroacetylphosphonium ylide; pyrazole; diazomethane; phenyl azide