2311-59-3

Basic information

• Product Name: N-CAPRIC ACID ISOPROPYL ESTER
• Synonyms: ISOPROPYL N-DECANOATE;ISOPROPYL DECANOATE;ISOPROPYL CAPRATE;N-DECANOIC ACID ISOPROPYL ESTER;N-CAPRIC ACID ISOPROPYL ESTER;1-Methylethyldecanoate;capricacidisopropylester;Decanoicacid,1-methylethylester
• CAS NO: 2311-59-3
• Molecular Formula: C₁₃H₂₆O₂
• Molecular Weight: 214.34
• EINECS: 219-001-4
• Mol File: 2311-59-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 89 °C / 2mmHg
• Flash Point: 122 °C
• Appearance: /
• Density: 0.86
• Refractive Index: 1.4220-1.4250
• CAS DataBase Reference: N-CAPRIC ACID ISOPROPYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: N-CAPRIC ACID ISOPROPYL ESTER(2311-59-3)
• EPA Substance Registry System: N-CAPRIC ACID ISOPROPYL ESTER(2311-59-3)

Safety Data

• Hazardous Substances Data: 2311-59-3(Hazardous Substances Data)

Usage

General Description

N-Capric Acid Isopropyl Ester, also known as Isopropyl Decanoate, is a chemical compound often used in a wide range of applications such as in the formulation of skincare and cosmetic products due to its properties as a conditioning agent. It is known to enhance the appearance and feel of hair by improving its body, suppleness, and sheen. Moreover, it improves the texture of skin, primarily by providing lubrication and reducing roughness. As an ester of isopropyl alcohol and capric acid, this chemical is generally characterized by a fruity or floral aroma, which makes it a valuable additive in the production of perfumes and flavorings.

Upstream product

• 67-63-0 isopropyl alcohol 
• 112-13-0 n-decanoyl chloride 
• 334-48-5 1-decanoic acid 
• 112-31-2 caprinaldehyde 
• 693-04-9 butyl magnesium bromide 
• 64135-07-5 isopropyl 6-bromohexanoic acid ester 
• 75-26-3 isopropyl bromide 
• 4353-06-4 2-n-nonyl-1,3-dioxolane 

Downstream Products

• 1351766-64-7 (R)-3-ethoxy-3-oxo-1-phenylpropyl decanoate 
• 72656-47-4 ethyl (R)-3-hydroxy-3-phenylpropanoate 
• 33401-74-0 ethyl (3R)-3-hydroxy-3-phenylpropionate 
• 1975-78-6 n-decanenitrile 

Relevant articles and documents

Generation and trapping of ketenes in flow

Ketenes were generated by the thermolysis of alkoxyalkynes under flow conditions, and then trapped with amines and alcohols to cleanly give amides and esters. For a 10 min reaction time, temperatures of 180, 160, and 140 °C were required for >95% conversion of EtO, iPrO, and tBuO alkoxyalkynes, respectively. Variation of the temperature and flow rate with inline monitoring of the output by IR spectroscopy allowed the kinetic parameters for the conversion of 1-ethoxy-1-octyne to be easily estimated (Ea = 105.4 kJ/mol). Trapping of the in-situ-generated ketenes by alcohols to give esters required the addition of a tertiary amine catalyst to prevent competitive [2+2] addition of the ketene to the alkoxyalkyne precursor.

Organocatalytic oxidation of aldehydes to mixed anhydrides

TEMPO catalyzes the direct oxidation of aldehydes to mixed anhydrides in the presence of a carboxylic acid. The anhydrides can be converted in situ to esters, secondary, tertiary or Weinreb amides in high yield. Oxidation of the aldehyde directly to 2-propyl esters is also possible using only catalytic amounts of acid. The oxidation reactions are rapid and take place under mild conditions.

Synthesis and evaluation of different fatty acid esters formulated into Precirol ATO-based lipid nanoparticles as vehicles for topical delivery

A series of isopropyl fatty esters having different chain length (C 13-C23) were synthesized and formulated in lipid nanoparticles based on Precirol ATO to evaluate their effect on the physicochemical properties of these latter. Moreover, drug loading and skin permeation of Econazole nitrate, chosen as a lipophilic model drug, were evaluated as well. The obtained nanosystems, prepared by high shear homogenization method, had a mean diameter ranging from 180 to 280 nm and showed an encapsulation efficiency of about 100%. Ex vivo permeation results demonstrated a parabolic correlation between permeation effect and chain length of the fatty esters present in the lipid nanoparticles formulated in hydrophilic gels. The maximum flux of drug was observed for the nanoparticles containing esters with 17 and 19 carbon atoms, suggesting that these formulations may constitute a potential carrier for topical delivery of econazole nitrate.