23145-07-5

Basic information

• Product Name: 5-Bromo-1-benzofuran
• Synonyms: 5-BROMO-1-BENZOFURAN;5-BROMOBENZO[BETA]FURAN;5-BROMOBENZOFURAN;BUTTPARK 95\50-66;5-Bromobenzo[b]furan;5-Bromobenzo[beta]furan, 98 %;5-Bromobenzofuran ,97%;Benzofuran, 5-broMo-
• CAS NO: 23145-07-5
• Molecular Formula: C₈H₅BrO
• Molecular Weight: 197.03
• Product Categories: pharmacetical
• Mol File: 23145-07-5.mol
• Article Data: 34

Chemical Properties

• Melting Point: 8°C(lit.)
• Boiling Point: 226°C(lit.)
• Flash Point: 95.2 °C
• Appearance: Colorless to pale yellow liquid
• Density: 1.573 g/mL at 25 °C
• Vapor Pressure: 0.0835mmHg at 25°C
• Refractive Index: n20/D1.605
• Storage Temp.: Refrigerated.
• CAS DataBase Reference: 5-Bromo-1-benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-1-benzofuran(23145-07-5)
• EPA Substance Registry System: 5-Bromo-1-benzofuran(23145-07-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 23145-07-5(Hazardous Substances Data)

Usage

Description

5-Bromo-1-benzofuran is a light yellow liquid with unique chemical properties that make it a valuable compound in various applications.

Uses

Used in Pharmaceutical Industry:
5-Bromo-1-benzofuran is used as a key intermediate in the synthesis of 1-(7-benzofuranyl)-4-methylpiperazine, a compound that exhibits strong and selective binding to the serotonin receptor 5-HT2A, even in the presence of the receptor 5-HT7. This selective binding property makes it a promising candidate for the development of drugs targeting serotonin-related disorders.
Used in Chemical Synthesis:
As a light yellow liquid with specific chemical properties, 5-Bromo-1-benzofuran can be utilized in the synthesis of various other organic compounds, contributing to the advancement of chemical research and the development of new materials and pharmaceuticals.

InChI:InChI=1/C8H5BrO/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5H

Upstream product

• 106-41-2 4-bromo-phenol 
• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 13997-74-5 2-allyl-4-bromophenol 
• 104743-20-6 2-allyl-1-allyloxy-4-bromobenzene 
• 96853-37-1 4-Bromo-2-(2-nitro-ethyl)-phenol 
• 129969-69-3 1-bromo-4'-(2,2-dimethoxyethoxy)benzene 
• 271-89-6 1-benzofurane 
• 66826-78-6 5-bromo-2,3-dihydrobenzo[b]furan 
• 112598-18-2 1-bromo-4-(2,2-diethoxyethoxy)benzene 
• 79-11-8 chloroacetic acid 
• 1761-61-1 5-bromosalicyclaldehyde 
• 591-20-8 3-Bromophenol 
• 204452-94-8 2-(3-bromophenoxy)acetaldehyde diethyl acetal 
• 24589-89-7 2-(4-bromo-2-formylphenoxy)acetic acid 

Downstream Products

• 10035-16-2 benzofuran-5-carbaldehyde 
• 79002-39-4 benzo[b]furan-5-carbonitrile 
• 331834-03-8 5-(4-pentyl-phenyl)-benzofuran 
• 331833-99-9 (5-bromobenzofuran-2-yl)boronic acid 
• 64150-67-0 2,3,5-tribromobenzofuran 
• 568593-05-5 2,3,5-tribromo-2,3-dihydrobenzofuran 
• 271-89-6 1-benzofurane 
• 58546-89-7 1-benzofuran-5-amine 
• 54965-04-7 5-bromo-2-methylbenzo[b]furan 

Relevant articles and documents

Substitution vs. addition. Regioselective electro-bromination of benzofuran

Regioselective electro-bromination of benzofuran (2) was achieved successfully by an adequate choice of solvents and bromide salts to afford 5-bromobenzofuran (1), 5,7-dibromobenzofuran (3), and 2,3-dibromo-2,3-dihydrobenzofuran (4), respectively. Upon electrolysis of benzofuran (2) in AcOH/H2O (100/1) containing NH4Br, substitution at the C(5)-position of benzofuran (2) proceeded smoothly to afford 5-bromobenzofuran (1). After passage of totally 4 F/mol of electricity in a similar medium, 5,7-dibromobenzofuran (3) was obtained as a sole product. On the other hand, electrolysis of benzofuran (2) in CH2Cl2/H2O (1/1) and/or AcOH/H2O (10/1) in the presence of either NaBr or NH4Br afforded 2,3-dibromo-2,3-dihydrobenzofuran (4), exclusively.

REACTIVE MESOGEN, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY COMPRISING THE SAME

The invention relates to a reactive mesogen, a liquid crystal composition and a liquid crystal display comprising the same. The reactive mesogen is represented by a chemical formula 1, wherein, X1 andX2 independently are hydrogen or halogen, Y is -O-, -S-

Dioxazolones as masked ester surrogates in the Pd(ii)-catalyzed direct C-H arylation of 6,5-fused heterocycles

A simple and effective Pd(ii)-catalyzed regioselective C(2)-H arylation of 6,5-fused heterocycles with dioxazolones as a masked ester surrogate under mild conditions is reported. The significance of the arylation is highlighted by the new reactivity demonstrated in dioxazolones via proximal C-H activation of the cyclic carbonate of the hydroxamic acid functionality under protic conditions.