23145-99-5

Basic information

• Product Name: Piperazine, 1-(3-chloropropyl)-4-(phenylmethyl)-
• CAS NO: 23145-99-5
• Molecular Formula: C14H21ClN2
• Molecular Weight: 252.787
• Mol File: 23145-99-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-(3-chloropropyl)-4-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(3-chloropropyl)-4-(phenylmethyl)-(23145-99-5)
• EPA Substance Registry System: Piperazine, 1-(3-chloropropyl)-4-(phenylmethyl)-(23145-99-5)

Safety Data

• Hazardous Substances Data: 23145-99-5(Hazardous Substances Data)

Upstream product

• 2759-28-6 1-phenylmethylpiperazine 
• 7440-44-0 pyrographite 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 93699-34-4 1-(4-Chlorophenyl)-1-{4-[3-(4-benzyl-piperazin-1-yl)-propoxy]-phenyl}-propan-1-ol 
• 1034266-45-9 C₂₄H₂₉N₃O₂S 
• 1034266-09-5 C₂₁H₂₉N₃O₃S 
• 1363773-47-0 3-(4-benzylpiperazino)propyl [5-(4-fluorophenyl)-4H-1,2,4-triazol-3-yl]sulfide 
• 1350839-70-1 2-[3-(4-benzylpiperazin-1-yl)propyl]-4-furan-2-ylmethyl-6-phenyl-2H-pyridazin-3-one 
• 1350839-68-7 4-benzyl-2-[3-(4-benzylpiperazin-1-yl)propyl]-6-phenyl-2H-pyridazin-3-one 
• 1250257-10-3 C₂₃H₂₈N₄OS 
• 1250257-12-5 C₂₂H₂₅ClN₄OS 
• 1250257-11-4 C₂₃H₂₈N₄OS 
• 1456543-23-9 1-[3-(4-benzylpiperazino)propyl]-3-(4-fluorophenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thione 

Relevant articles and documents

Synthesis, characterization, and anticancer studies of S and N alkyl piperazine-substituted positional isomers of 1,2,4-triazole derivatives

A series of 3-[3-[4-(substituted)-1-cyclicamine] propyl]thio-5- substituted[1,2,4]triazoles (8a-m) and 2-[3-[4-(substituted)-1-cyclicamine] propyl]-5-(substituted)-2,4-dihydro-3H[1,2,4]triazole-3-thiones (9a-h) were synthesized with good yields starting from corresponding carboxylic acids using two different methods. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Six compounds had shown good anticancer activity. The triazole derivatives, 9d, 8j, and 8i were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinant of their biological activity. Springer Science+Business Media 2013.

Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substitutedpiperazine-1-yl) propyl]pyridazin-3(2H)-one derivatives as anticancer agents

A series of new 4-(aryl/heteroaryl-2-ylmethyl)- 6-phenyl-2-[3-(4- substituted piperazine-1-yl)propyl] pyridazin- 3(2H)-one derivatives were synthesized. The structures of the compounds were confirmed by IR, 1H NMR, and mass spectral data. All the compounds were evaluated for their cytotoxicity toward five human cancer cell lines of different origins viz; HeLa (Cervical), SKBR3 (Breast), HCT116 (Colon), A375 (Skin) & H1299 (Lung) at different concentrations and the IC50 values were determined. HCT116 and HeLa are the most sensitive against the compounds studied. One of them displayed moderate cytotoxicity against SKBR3. Majority of the compounds exhibited good to moderate activity.

Microwave-assisted solvent-free synthesis of 3-[(4-substituted piperazin-1-yl)alkyl] imidazo[2,1-b][1,3]benzothiazol-2(3H)-ones as serotonin3 (5-HT3) receptor antagonists

A series of novel 3-[(4-substituted piperazin-1-yl)alkyl]imidazo[2,1-b][1, 3]benzothiazol-2(3H)-ones were prepared by microwave irradiation using alumina as solid support and also by a conventional method. The compounds were characterized by spectral data and the purity was ascertained by microanalysis. The synthesized compounds were evaluated for 5-hydroxytryptamine3 antagonisms in a longitudinal muscle-myenteric plexus preparation from guinea pig ileum against the 5-hydroxytryptamine3 agonist, 2-methyl-5-hydroxytryptamine. Among the test compounds, 3-[2-(4-methylpiperazin- 1-yl)ethyl]imidazo[2,1-6][1,3]benzothiazol-2(3H)-one (3b) showed most favorable 5-hydroxytryptamine3 antagonism (pA2 6.7) in the isolated guinea pig ileum.