23146-07-8Relevant articles and documents
Synthesis of AZT analogues: 7-(3-azido-2hydroxypropyl)-, 7-(3-amino-2-hydroxypropyl)-, 7-(3-triazolyl-2-hydroxypropyl)theophyllines
El Ashry, El Sayed,Abdel-Rahman, Adel,Rashed, Nagwa,Awad, Laila,Rasheed, Hanaa
, p. 299 - 305 (2006)
Nucleophilic displacement of the tosyloxy group in 7-(2-hydroxy-3- p -toluenesulfonyloxypropyl)theophylline (1) with azide anion afforded 7-(3-azido-2-hydroxypropyl)theophylline (2). Reduction of the 3-azido group in 2 with Ph 3 P/Py/NH 4 OH afforded the 3-amino derivative 4, alternatively obtained by regioselective amination of 7-(2,3-epoxypropyl)theophylline (3). Selective acetylation of 4 gave the N-acetyl derivative 5. 1,3-Dipolar cycloaddition of the azide group in 2 with N 1 -propargyl thymine (6) afforded the regioisomeric triazole 7. Copyright Taylor & Francis Group, LLC.
Substituted epoxyalkyl xanthines
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, (2008/06/13)
Compounds of the formula STR1 including the resolved enantiomers and/or diastereomers and mixtures thereof wherein each of one or two R is independently STR2 wherein n is 1-16 and R' is H or alkyl(1-4C); and wherein each remaining R is independently H, alkyl(1-6C), alkenyl(1-6C) or benzyl; an wherein said alkyl or alkenyl may be substituted by a hydroxyl, halo, or dimethylamino group, and/or interrupted by an oxygen atom, are useful in modulating the effects of internal and external stimuli on cells by reversing the effects of these stimuli on the short-term secondary messenger pathways. In particular, the compounds lower elevated levels of unsaturated, non-arachidonate phosphatidic acid (PA) and diacylglycerol (DAG) derived from said PA within seconds of the primary stimulus and their contact with said cells. The modulatory effect depends on the nature of the target cell and the stimulus applied.
Piperazine derivatives of dimethylxanthines. IV. Reaction of β,γ epoxypropyldimethylxanthines with piperazines
Zejc,Gorczyca,Kiec Kononowicz,Pawlowski
, p. 369 - 374 (2007/10/04)
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