2316-62-3Relevant articles and documents
Synthesis of biaryl compounds through three-component assembly: Ambidentate effect of the tert-butyldimethylsilyl group for regioselective diels-alder and hiyama coupling reactions
Akai, Shuji,Ikawa, Takashi,Takayanagi, Sho-Ichi,Morikawa, Yuki,Mohri, Shinya,Tsubakiyama, Masaya,Egi, Masahiro,Wada, Yasufumi,Kita, Yasuyuki
supporting information; experimental part, p. 7673 - 7676 (2009/04/10)
Two for the price of one: A method has been developed for the regiocontrolled synthesis of multisubstituted biaryl derivatives. This protocol involves the use of the tert-butyldimethylsilyl (TBDMS) group to direct the regioselective Diels-Alder reaction of a 3-TBDMS-benzyne with a furan derivative and a subsequent Hiyama cross-coupling reaction of the TBDMS group with aryl iodides (see scheme).